Version 5.4
Homo sapiens Protein: REEP4
Summary
InnateDB Protein IDBP-10310.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol REEP4
Protein Name receptor accessory protein 4
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000303482
InnateDB Gene IDBG-10308 (REEP4)
Protein Structure
UniProt Annotation
Function Microtubule-binding protein required to ensure proper cell division and nuclear envelope reassembly by sequestering the endoplasmic reticulum away from chromosomes during mitosis. Probably acts by clearing the endoplasmic reticulum membrane from metaphase chromosomes. {ECO:0000269PubMed:23911198}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000269PubMed:23911198}; Multi-pass membrane protein {ECO:0000269PubMed:23911198}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008017 microtubule binding
Biological Process
GO:0006998 nuclear envelope organization
GO:0007067 mitotic nuclear division
GO:0007084 mitotic nuclear envelope reassembly
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005874 microtubule
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR004345 TB2/DP1/HVA22-related protein
PFAM PF03134
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9H6H4
PhosphoSite PhosphoSite-Q9H6H4
TrEMBL
UniProt Splice Variant
Entrez Gene 80346
UniGene Hs.695067
RefSeq NP_079508
HUGO HGNC:26176
OMIM 609349
CCDS CCDS6024
HPRD 09864
IMGT
EMBL AC105206 AF218014 AK025899 AK025930 AK172846 AY562242 BC013048 BC050622 CH471080 CR457353
GenPept AAG17256 AAH13048 AAH50622 AAT70687 BAB15274 BAB15285 BAD18810 CAG33634 EAW63710 EAW63715

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca