InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SKAP2

Summary

InnateDB Protein

IDBP-10243.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SKAP2

Protein Name

src kinase associated phosphoprotein 2

Synonyms

PRAP; RA70; SAPS; SCAP2; SKAP-HOM; SKAP55R;

Species

Homo sapiens

Ensembl Protein

ENSP00000005587

InnateDB Gene

IDBG-10241 (SKAP2)

Protein Structure

UniProt Annotation

Function

May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. {ECO:0000269PubMed:12893833, ECO:0000269PubMed:9837776}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12893833}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Present in platelets (at protein level). {ECO:0000269PubMed:10942756, ECO:0000269PubMed:9755858, ECO:0000269PubMed:9837776}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005070	SH3/SH2 adaptor activity
GO:0005515	protein binding

Biological Process

GO:0006461	protein complex assembly
GO:0007165	signal transduction
GO:0008285	negative regulation of cell proliferation
GO:0009967	positive regulation of signal transduction
GO:0042113	B cell activation