InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: AHRR

Summary

InnateDB Protein

IDBP-10198.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AHRR

Protein Name

aryl-hydrocarbon receptor repressor

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000323816

InnateDB Gene

IDBG-10192 (AHRR)

Protein Structure

UniProt Annotation

Function

Mediates dioxin toxicity and is involved in regulation of cell growth and differentiation. Represses the transcription activity of AHR by competing with this transcription factor for heterodimer formation with the ARNT and subsequently binding to the xenobiotic response element (XRE) sequence present in the promoter regulatory region of variety of genes. Represses CYP1A1 by binding the XRE sequence and recruiting ANKRA2, HDAC4 and/or HDAC5. Autoregulates its expression by associating with its own XRE site. {ECO:0000269PubMed:17890447, ECO:0000269PubMed:18172554}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:17980155}. Nucleus {ECO:0000255PROSITE-ProRule:PRU00981, ECO:0000269PubMed:17980155}. Note=Predominantly in the nuclear compartment. First cytoplasmic, translocates into the nuclear compartment upon interaction with ARNT in the cytoplasmic compartment.

Disease Associations

Tissue Specificity

Highly expressed in testis, lung, ovary, spleen and pancreas. Highly expressed in mononuclear cells (MNCs) from umbilical cord blood. Isoform 3 is highly expressed in lung, kidney, spleen and thymus. Down-regulated malignant tissue from different anatomical origins, including colon, breast, lung, stomach, cervix, and ovary. {ECO:0000269PubMed:11835227, ECO:0000269PubMed:14672759, ECO:0000269PubMed:18172554}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0004871	signal transducer activity
GO:0046983	protein dimerization activity

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0033235	positive regulation of protein sumoylation
GO:0045892	negative regulation of transcription, DNA-templated