InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CBX3

Summary

InnateDB Protein

IDBP-10173.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CBX3

Protein Name

chromobox homolog 3

Synonyms

HECH; HP1-GAMMA; HP1Hs-gamma;

Species

Homo sapiens

Ensembl Protein

ENSP00000336687

InnateDB Gene

IDBG-10171 (CBX3)

Protein Structure

UniProt Annotation

Function

Seems to be involved in transcriptional silencing in heterochromatin-like complexes. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. May contribute to the association of the heterochromatin with the inner nuclear membrane through its interaction with lamin B receptor (LBR). Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins. Contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 'Lys-9' trimethylation, mediates the recruitment of the mehtyltransferases SUV39H1 and/or SUV39H2 by the PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1.

Subcellular Localization

Nucleus {ECO:0000305}. Note=Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Experimentally validated
Total	126 [view]
Protein-Protein	122 [view]
Protein-DNA	3 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019899	enzyme binding
GO:0019904	protein domain specific binding
GO:0042802	identical protein binding
GO:1990226	histone methyltransferase binding

Biological Process

GO:0006338	chromatin remodeling
GO:0006351	transcription, DNA-templated
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048511	rhythmic process

Cellular Component

GO:0000779	condensed chromosome, centromeric region
GO:0000785	chromatin
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005637	nuclear inner membrane
GO:0005719	nuclear euchromatin
GO:0005720	nuclear heterochromatin
GO:0005819	spindle
GO:0031618	nuclear centromeric heterochromatin