Version 5.4
Homo sapiens Gene: DOK2
Summary
InnateDB Gene IDBG-9913.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DOK2
Gene Name docking protein 2, 56kDa
Synonyms p56DOK; p56dok-2
Species Homo sapiens
Ensembl Gene ENSG00000147443
Encoded Proteins
IDBP-9915
docking protein 2, 56kDa
IDBP-473365
docking protein 2, 56kDa
IDBP-473552
docking protein 2, 56kDa
IDBP-481289
docking protein 2, 56kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:21908873-21913860
Strand Reverse strand
Band p21.3
Transcripts
ENST00000276420 ENSP00000276420
ENST00000524001
ENST00000517422 ENSP00000429508
ENST00000518197 ENSP00000430729
ENST00000523932 ENSP00000429224
ENST00000522011
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 23 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005057 receptor signaling protein activity
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005158 insulin receptor binding
Biological Process
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007265 Ras protein signal transduction
GO:0007596 blood coagulation
GO:0050900 leukocyte migration
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022102
View Gene Order
ENSBTAG00000003341
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_11
TCR pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_24
TSLP pathway
REACTOME
REACT_12621
Tie2 Signaling pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
il2_1pathway
IL2-mediated signaling events
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt
TrEMBL G3V114
UniProt Splice Variant
Entrez Gene 9046
UniGene Hs.71215
RefSeq NM_003974
HUGO HGNC:2991
OMIM 604997
CCDS CCDS6016
HPRD 05411
IMGT
EMBL AC087363 CH471080
GenPept EAW63740
RNA Seq Atlas 9046

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca