Homo sapiens Gene: EIF2S1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-9859.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | EIF2S1 | ||||||||||||||||||||||
Gene Name | eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa | ||||||||||||||||||||||
Synonyms | EIF-2; EIF-2A; EIF-2alpha; EIF2; EIF2A | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000134001 | ||||||||||||||||||||||
Encoded Proteins |
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 14:67359997-67386516 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q23.3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
IL1 pathway
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REACTOME |
L13a-mediated translational silencing of Ceruloplasmin expression pathway
PERK regulates gene expression pathway
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
Translation initiation complex formation pathway
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
Formation of the ternary complex, and subsequently, the 43S complex pathway
Recycling of eIF2:GDP pathway
Ribosomal scanning and start codon recognition pathway
Eukaryotic Translation Initiation pathway
Unfolded Protein Response (UPR) pathway
Translation pathway
Metabolism of proteins pathway
Cap-dependent Translation Initiation pathway
Gene Expression pathway
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KEGG |
RNA transport pathway
Protein processing in endoplasmic reticulum pathway
Hepatitis C pathway
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INOH | |||||||||||||||||||||||
PID NCI |
Validated targets of C-MYC transcriptional activation
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 1965 | ||||||||||||||||||||||
UniGene | Hs.151777 Hs.597347 Hs.599838 | ||||||||||||||||||||||
RefSeq | NM_004094 | ||||||||||||||||||||||
HUGO | HGNC:3265 | ||||||||||||||||||||||
OMIM | 603907 | ||||||||||||||||||||||
CCDS | CCDS9781 | ||||||||||||||||||||||
HPRD | 04881 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 1965 | ||||||||||||||||||||||