Version 5.4
Homo sapiens Gene: EIF3J
Summary
InnateDB Gene IDBG-9813.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3J
Gene Name eukaryotic translation initiation factor 3, subunit J
Synonyms eIF3-alpha; eIF3-p35; EIF3S1
Species Homo sapiens
Ensembl Gene ENSG00000104131
Encoded Proteins
IDBP-9815
eukaryotic translation initiation factor 3, subunit J
IDBP-371128
eukaryotic translation initiation factor 3, subunit J
IDBP-600307
eukaryotic translation initiation factor 3, subunit J
IDBP-599258
eukaryotic translation initiation factor 3, subunit J
IDBP-595406
eukaryotic translation initiation factor 3, subunit J
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Eukaryotic initiation factor-3 (EIF3) has a molecular mass of about 600 kD and contains 13 nonidentical protein subunits, including EIF3J. EIF3 plays a central role in binding of initiator methionyl-tRNA and mRNA to the 40S ribosomal subunit to form the 40S initiation complex (Fraser et al., 2004 [PubMed 14688252]; Fraser et al., 2007 [PubMed 17588516]).[supplied by OMIM, Mar 2008]
This gene encodes a core subunit of the eukaryotic initiation factor 3 complex, which participates in the initiation of translation by aiding in the recruitment of protein and mRNA components to the 40S ribosome. There are pseudogenes for this gene on chromosomes 1, 3, and 9. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:44537057-44563029
Strand Forward strand
Band q21.1
Transcripts
ENST00000261868 ENSP00000261868
ENST00000424492 ENSP00000414548
ENST00000535391 ENSP00000440221
ENST00000558227
ENST00000558053
ENST00000536248 ENSP00000443563
ENST00000558353 ENSP00000453282
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
Experimentally validated
Total 35 [view]
Protein-Protein 35 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000043424
View Gene Order
ENSBTAG00000000359
Not yet available
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 8669
UniGene Hs.404056 Hs.607689 Hs.695256 Hs.735826
RefSeq NM_001284335 NM_001284336 NM_003758
HUGO HGNC:3270
OMIM 603910
CCDS CCDS10111 CCDS61612 CCDS61613
HPRD 04883
IMGT
EMBL
GenPept
RNA Seq Atlas 8669

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca