InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IGF2BP3

Summary

InnateDB Gene

IDBG-9675.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IGF2BP3

Gene Name

insulin-like growth factor 2 mRNA binding protein 3

Synonyms

CT98; IMP-3; IMP3; KOC; KOC1; VICKZ3

Species

Homo sapiens

Ensembl Gene

ENSG00000136231

Encoded Proteins

IDBP-9679

insulin-like growth factor 2 mRNA binding protein 3

IDBP-368158

insulin-like growth factor 2 mRNA binding protein 3

IDBP-812270

insulin-like growth factor 2 mRNA binding protein 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5\' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:23310209-23470467

Strand

Reverse strand

Band

p15.3

Transcripts

ENST00000258729	ENSP00000258729
ENST00000421467	ENSP00000395936
ENST00000498363
ENST00000467592
ENST00000497563
ENST00000480547
ENST00000495009
ENST00000468263
ENST00000492771
ENST00000479504
ENST00000466809
ENST00000491719
ENST00000465058
ENST00000469723
ENST00000474105
ENST00000476938
ENST00000468005
ENST00000619562	ENSP00000480267

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 67 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	67 [view]
Protein-Protein	67 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0003730	mRNA 3'-UTR binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding
GO:0045182	translation regulator activity
GO:0048027	mRNA 5'-UTR binding

Biological Process

GO:0006412	translation
GO:0009653	anatomical structure morphogenesis
GO:0010467	gene expression
GO:0017148	negative regulation of translation
GO:0042035	regulation of cytokine biosynthetic process
GO:0051028	mRNA transport

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000029814

View Gene Order

ENSBTAG00000019406

Not yet available

Pathways

NETPATH

REACTOME

REACT_22166

Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA pathway

REACT_71

Gene Expression pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.700696

RefSeq

NM_006547 XM_006715638 XM_006715639

HUGO

OMIM

CCDS

CCDS5382

HPRD

16306

IMGT

EMBL

GenPept

RNA Seq Atlas