InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GFER

Summary

InnateDB Gene

IDBG-9655.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GFER

Gene Name

growth factor, augmenter of liver regeneration

Synonyms

ALR; ERV1; HERV1; HPO; HPO1; HPO2; HSS

Species

Homo sapiens

Ensembl Gene

ENSG00000127554

Encoded Proteins

IDBP-9657

growth factor, augmenter of liver regeneration

IDBP-750327

IDBP-748247

IDBP-750644

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]
The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42%% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:1984207-1987749

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000248114	ENSP00000248114
ENST00000561710	ENSP00000456189
ENST00000565658
ENST00000567719	ENSP00000455885
ENST00000569451	ENSP00000456432

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0015035	protein disulfide oxidoreductase activity
GO:0016972	thiol oxidase activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006626	protein targeting to mitochondrion
GO:0044267	cellular protein metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005758	mitochondrial intermembrane space

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040888

View Gene Order

ENSBTAG00000017631

Not yet available

Pathways

NETPATH

REACTOME

REACT_118595

Mitochondrial protein import pathway

REACT_17015

Metabolism of proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.27184

RefSeq

NM_005262

HUGO

OMIM

CCDS

CCDS32368

HPRD

02954

IMGT

EMBL

GenPept

RNA Seq Atlas