Version 5.4
Homo sapiens Gene: GPNMB
Summary
InnateDB Gene IDBG-9627.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GPNMB
Gene Name glycoprotein (transmembrane) nmb
Synonyms HGFIN; NMB
Species Homo sapiens
Ensembl Gene ENSG00000136235
Encoded Proteins
IDBP-9629
glycoprotein (transmembrane) nmb
IDBP-9631
glycoprotein (transmembrane) nmb
IDBP-294860
glycoprotein (transmembrane) nmb
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a type I transmembrane glycoprotein which shows homology to the pMEL17 precursor, a melanocyte-specific protein. GPNMB shows expression in the lowly metastatic human melanoma cell lines and xenografts but does not show expression in the highly metastatic cell lines. GPNMB may be involved in growth delay and reduction of metastatic potential. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:23235967-23275108
Strand Forward strand
Band p15.3
Transcripts
ENST00000381990 ENSP00000371420
ENST00000258733 ENSP00000258733
ENST00000409458 ENSP00000386476
ENST00000465673
ENST00000492858
ENST00000459927
ENST00000487890
ENST00000474157
ENST00000492512
ENST00000479625
ENST00000470994
ENST00000463011
ENST00000478451
ENST00000468723
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005178 integrin binding
GO:0008201 heparin binding
Biological Process
GO:0001649 osteoblast differentiation
GO:0007155 cell adhesion
GO:0008285 negative regulation of cell proliferation
GO:0030282 bone mineralization
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0042470 melanosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029816
View Gene Order
ENSBTAG00000000604
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.190495 Hs.605668 Hs.639968
RefSeq NM_001005340 NM_002510 XM_005249578
HUGO
OMIM
CCDS CCDS34610 CCDS5380
HPRD 05081
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca