InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS2

Summary

InnateDB Gene

IDBG-9488.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS2

Gene Name

ribosomal protein S2

Synonyms

LLREP3; S2

Species

Homo sapiens

Ensembl Gene

ENSG00000140988

Encoded Proteins

IDBP-9490

ribosomal protein S2

IDBP-584465

ribosomal protein S2

IDBP-752844

IDBP-596253

ribosomal protein S2

IDBP-587611

ribosomal protein S2

IDBP-599496

ribosomal protein S2

IDBP-586569

ribosomal protein S2

IDBP-601745

ribosomal protein S2

IDBP-752364

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:1962052-1964860

Strand

Reverse strand

Band

p13.3

Transcripts

ENST00000343262	ENSP00000341885
ENST00000526522	ENSP00000436865
ENST00000526586	ENSP00000460860
ENST00000533186	ENSP00000436227
ENST00000532746	ENSP00000434846
ENST00000533872
ENST00000527109
ENST00000527871
ENST00000530225	ENSP00000436356
ENST00000531065
ENST00000533161
ENST00000529806	ENSP00000433170
ENST00000534461
ENST00000527302	ENSP00000433034
ENST00000526908
ENST00000527826
ENST00000563194	ENSP00000454837

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 193 experimentally validated interaction(s) in this database.

Experimentally validated
Total	193 [view]
Protein-Protein	192 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0003729	mRNA binding
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0017134	fibroblast growth factor binding
GO:0019899	enzyme binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0044267	cellular protein metabolic process
GO:0051347	positive regulation of transferase activity

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0015935	small ribosomal subunit
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0070062	extracellular vesicular exosome