InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SREBF2

Summary

InnateDB Gene

IDBG-9448.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SREBF2

Gene Name

sterol regulatory element binding transcription factor 2

Synonyms

bHLHd2; SREBP-2; SREBP2

Species

Homo sapiens

Ensembl Gene

ENSG00000198911

Encoded Proteins

IDBP-9450

sterol regulatory element binding transcription factor 2

IDBP-378428

sterol regulatory element binding transcription factor 2

IDBP-378431

sterol regulatory element binding transcription factor 2

IDBP-806856

sterol regulatory element binding transcription factor 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21408089

SREBF2 is a key transcriptional regulator of sterol biosynthesis in lipid metabolism, and SREBP2 protein levels in macrophages are negatively regulated by type I interferon signalling during viral infection. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21408089

[Mus musculus] Srebf2 is a key transcriptional regulator of sterol biosynthesis in lipid metabolism, and Srebp2 protein levels in macrophages are negatively regulated by type I interferon signalling during viral infection.

PMID 26938778

[Mus musculus] Mir342 is involved in a novel post-transcriptional viral defence mechanism in IFN-activated macrophages by directly targeting Srebf2, Idi1, Dhcr7 and Sc4mol of the sterol pathway.

Entrez Gene

Summary

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain. [provided by RefSeq, Jul 2008]
This gene encodes a member of the a ubiquitously expressed transcription factor that controls cholesterol homeostasis by regulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain and binds the sterol regulatory element 1 motif. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:41833079-41907308

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000361204	ENSP00000354476
ENST00000424354	ENSP00000395728
ENST00000435061	ENSP00000412287
ENST00000462539
ENST00000464119
ENST00000491541
ENST00000463741
ENST00000490262
ENST00000612482	ENSP00000484441

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 81 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	81 [view]
Protein-Protein	73 [view]
Protein-DNA	7 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0044212	transcription regulatory region DNA binding
GO:0046983	protein dimerization activity
GO:0070888	E-box binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006629	lipid metabolic process
GO:0008203	cholesterol metabolic process
GO:0010886	positive regulation of cholesterol storage
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0055098	response to low-density lipoprotein particle stimulus
GO:0071499	cellular response to laminar fluid shear stress
GO:0072368	regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter
GO:0090370	negative regulation of cholesterol efflux
GO:2000188	regulation of cholesterol homeostasis

Cellular Component

GO:0000139	Golgi membrane
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005829	cytosol
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0032937	SREBP-SCAP-Insig complex