Version 5.4
Homo sapiens Gene: MAPK8IP3
Summary
InnateDB Gene IDBG-9184.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAPK8IP3
Gene Name mitogen-activated protein kinase 8 interacting protein 3
Synonyms JIP3; JSAP1; syd; SYD2
Species Homo sapiens
Ensembl Gene ENSG00000138834
Encoded Proteins
IDBP-9186
mitogen-activated protein kinase 8 interacting protein 3
IDBP-9190
mitogen-activated protein kinase 8 interacting protein 3
IDBP-751677
IDBP-807824
mitogen-activated protein kinase 8 interacting protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene shares similarity with the product of Drosophila syd gene, required for the functional interaction of kinesin I with axonal cargo. Studies of the similar gene in mouse suggested that this protein may interact with, and regulate the activity of numerous protein kinases of the JNK signaling pathway, and thus function as a scaffold protein in neuronal cells. The C. elegans counterpart of this gene is found to regulate synaptic vesicle transport possibly by integrating JNK signaling and kinesin-1 transport. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:1706183-1770317
Strand Forward strand
Band p13.3
Transcripts
ENST00000250894 ENSP00000250894
ENST00000356010 ENSP00000348290
ENST00000563868
ENST00000567352
ENST00000564868
ENST00000568271
ENST00000567849 ENSP00000454739
ENST00000561949
ENST00000561765
ENST00000566064
ENST00000562042
ENST00000568774
ENST00000566589
ENST00000570131
ENST00000564098
ENST00000610761 ENSP00000481780
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.
Experimentally validated
Total 32 [view]
Protein-Protein 31 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 14 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005078 MAP-kinase scaffold activity
GO:0005515 protein binding
GO:0008432 JUN kinase binding
GO:0019894 kinesin binding
GO:0019901 protein kinase binding
GO:0031434 mitogen-activated protein kinase kinase binding
GO:0031435 mitogen-activated protein kinase kinase kinase binding
Biological Process
GO:0001701 in utero embryonic development
GO:0007254 JNK cascade
GO:0007257 activation of JUN kinase activity
GO:0007411 axon guidance
GO:0007585 respiratory gaseous exchange
GO:0008104 protein localization
GO:0009791 post-embryonic development
GO:0010468 regulation of gene expression
GO:0016192 vesicle-mediated transport
GO:0030900 forebrain development
GO:0031175 neuron projection development
GO:0043507 positive regulation of JUN kinase activity
GO:0045666 positive regulation of neuron differentiation
GO:0046328 regulation of JNK cascade
GO:0048286 lung alveolus development
GO:0060425 lung morphogenesis
Cellular Component
GO:0000139 Golgi membrane
GO:0005737 cytoplasm
GO:0005790 smooth endoplasmic reticulum
GO:0005886 plasma membrane
GO:0030425 dendrite
GO:0030673 axolemma
GO:0043005 neuron projection
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024163
View Gene Order
ENSBTAG00000002211
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
fak_pathway
Signaling events mediated by focal adhesion kinase
arf6_traffickingpathway
Arf6 trafficking events
Cross-References
SwissProt Q9UPT6
TrEMBL E9PFH7
UniProt Splice Variant
Entrez Gene 23162
UniGene Hs.207763
RefSeq NM_001040439 NM_015133 XM_005255187 XM_005255188
HUGO HGNC:6884
OMIM 605431
CCDS CCDS10442 CCDS45379
HPRD
IMGT
EMBL AB028989 AC012180 AE006639 AK024437 AL031710 AL031717 AL031718 BC137123 BC137124 BC150266
GenPept AAI37124 AAI37125 AAI50267 AAK61290 BAA83018 BAB15727 CAB72318 CAM26364 CAM26394
RNA Seq Atlas 23162

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca