InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PDIA3

Summary

InnateDB Gene

IDBG-9160.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDIA3

Gene Name

protein disulfide isomerase family A, member 3

Synonyms

ER60; ERp57; ERp60; ERp61; GRP57; GRP58; HEL-S-269; HEL-S-93n; HsT17083; P58; PI-PLC

Species

Homo sapiens

Ensembl Gene

ENSG00000167004

Encoded Proteins

IDBP-9162

protein disulfide isomerase family A, member 3

IDBP-370681

protein disulfide isomerase family A, member 3

IDBP-370682

protein disulfide isomerase family A, member 3

IDBP-370683

protein disulfide isomerase family A, member 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:43746392-43773279

Strand

Forward strand

Band

q15.3

Transcripts

ENST00000300289	ENSP00000300289
ENST00000434494	ENSP00000398005
ENST00000446523	ENSP00000391111
ENST00000455250	ENSP00000389906
ENST00000469684
ENST00000497349

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 125 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	125 [view]
Protein-Protein	125 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003756	protein disulfide isomerase activity
GO:0004197	cysteine-type endopeptidase activity
GO:0004629	phospholipase C activity
GO:0005515	protein binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0016853	isomerase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0002474	antigen processing and presentation of peptide antigen via MHC class I
GO:0002479	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006457	protein folding
GO:0006508	proteolysis
GO:0006606	protein import into nucleus
GO:0006621	protein retention in ER lumen
GO:0006662	glycerol ether metabolic process
GO:0007165	signal transduction
GO:0018279	protein N-linked glycosylation via asparagine
GO:0034976	response to endoplasmic reticulum stress
GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045454	cell redox homeostasis
GO:0055114	oxidation-reduction process
GO:2001238	positive regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005783	endoplasmic reticulum
GO:0005788	endoplasmic reticulum lumen
GO:0005790	smooth endoplasmic reticulum
GO:0009986	cell surface
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome