Version 5.4
Homo sapiens Gene: RBX1
Summary
InnateDB Gene IDBG-8962.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RBX1
Gene Name ring-box 1, E3 ubiquitin protein ligase
Synonyms BA554C12.1; RNF75; ROC1
Species Homo sapiens
Ensembl Gene ENSG00000100387
Encoded Proteins
IDBP-8964
ring-box 1, E3 ubiquitin protein ligase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a RING finger-like domain-containing protein. The encoded protein interacts with cullin proteins and likely plays a role in ubiquitination processes necessary for cell cycle progression. This protein may also affect protein turnover. Related pseudogenes exist on chromosomes 2 and 5.[provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:40951347-40973309
Strand Forward strand
Band q13.2
Transcripts
ENST00000216225 ENSP00000216225
ENST00000476110
ENST00000467617
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 213 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 213 [view]
Protein-Protein 213 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0019788 NEDD8 ligase activity
GO:0031625 ubiquitin protein ligase binding
GO:0032403 protein complex binding
Biological Process
GO:0006281 DNA repair
GO:0006513 protein monoubiquitination
GO:0007219 Notch signaling pathway
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0030163 protein catabolic process
GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0045116 protein neddylation
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0071456 cellular response to hypoxia
Cellular Component
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0019005 SCF ubiquitin ligase complex
GO:0030891 VCB complex
GO:0031461 cullin-RING ubiquitin ligase complex
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0031463 Cul3-RING ubiquitin ligase complex
GO:0031464 Cul4A-RING E3 ubiquitin ligase complex
GO:0031465 Cul4B-RING E3 ubiquitin ligase complex
GO:0031466 Cul5-RING ubiquitin ligase complex
GO:0031467 Cul7-RING ubiquitin ligase complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022400
View Gene Order
ENSBTAG00000030225
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_115697
Prolactin receptor signaling pathway
REACT_116022
Nuclear signaling by ERBB4 pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_9453
Vif-mediated degradation of APOBEC3G pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160305
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_120916
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_120956
Cellular responses to stress pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_11045
Signaling by Wnt pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_206597
Degradation of GLI2 by the proteasome pathway
REACT_200841
degradation of DVL pathway
REACT_231645
GLI3 is processed to GLI3R by the proteasome pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_267605
Degradation of GLI1 by the proteasome pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_75774
Adaptive Immune System pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_6900
Immune System pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_121311
Cellular response to hypoxia pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_22232
Signaling by Interleukins pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_6185
HIV Infection pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
KEGG
hsa04310
Wnt signaling pathway pathway
hsa04350
TGF-beta signaling pathway pathway
hsa04110
Cell cycle pathway
hsa05211
Renal cell carcinoma pathway
hsa04120
Ubiquitin mediated proteolysis pathway
hsa04710
Circadian rhythm pathway
hsa03420
Nucleotide excision repair pathway
hsa05200
Pathways in cancer pathway
hsa04114
Oocyte meiosis pathway
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
hif1apathway
Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
Cross-References
SwissProt P62877
TrEMBL
UniProt Splice Variant
Entrez Gene 9978
UniGene
RefSeq NM_014248
HUGO HGNC:9928
OMIM 603814
CCDS CCDS14009
HPRD
IMGT
EMBL AF140598 AF142059 AK315722 AL080242 AY099360 BC001466 BC017370 CH471095 CR456560
GenPept AAD29715 AAD30146 AAH01466 AAH17370 AAM21718 BAG38078 CAB62925 CAG30446 EAW60403
RNA Seq Atlas 9978

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca