Version 5.4
Homo sapiens Gene: SYNE2
Summary
InnateDB Gene IDBG-8789.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SYNE2
Gene Name spectrin repeat containing, nuclear envelope 2
Synonyms EDMD5; Nesp2; Nesprin-2; NUA; NUANCE; SYNE-2; TROPH
Species Homo sapiens
Ensembl Gene ENSG00000054654
Encoded Proteins
IDBP-8791
spectrin repeat containing, nuclear envelope 2
IDBP-8793
spectrin repeat containing, nuclear envelope 2
IDBP-8795
spectrin repeat containing, nuclear envelope 2
IDBP-8801
spectrin repeat containing, nuclear envelope 2
IDBP-240578
spectrin repeat containing, nuclear envelope 2
IDBP-372198
spectrin repeat containing, nuclear envelope 2
IDBP-372201
spectrin repeat containing, nuclear envelope 2
IDBP-588417
spectrin repeat containing, nuclear envelope 2
IDBP-601860
spectrin repeat containing, nuclear envelope 2
IDBP-601413
spectrin repeat containing, nuclear envelope 2
IDBP-600701
spectrin repeat containing, nuclear envelope 2
IDBP-585881
spectrin repeat containing, nuclear envelope 2
IDBP-602496
spectrin repeat containing, nuclear envelope 2
IDBP-602321
spectrin repeat containing, nuclear envelope 2
IDBP-585238
spectrin repeat containing, nuclear envelope 2
IDBP-585737
spectrin repeat containing, nuclear envelope 2
IDBP-588710
spectrin repeat containing, nuclear envelope 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:63852983-64226433
Strand Forward strand
Band q23.2
Transcripts
ENST00000358025 ENSP00000350719
ENST00000344113 ENSP00000341781
ENST00000357395 ENSP00000349969
ENST00000341472 ENSP00000344528
ENST00000394768 ENSP00000378249
ENST00000458046 ENSP00000391937
ENST00000441438 ENSP00000396794
ENST00000556725
ENST00000554584 ENSP00000452570
ENST00000557005
ENST00000555002 ENSP00000450831
ENST00000557060
ENST00000555323
ENST00000553308 ENSP00000451520
ENST00000553455 ENSP00000452434
ENST00000555612 ENSP00000451972
ENST00000557024
ENST00000553289 ENSP00000451184
ENST00000556342
ENST00000555241
ENST00000553801
ENST00000556906 ENSP00000452298
ENST00000555022 ENSP00000451009
ENST00000553806
ENST00000554805 ENSP00000450605
ENST00000554997
ENST00000557307
ENST00000557084 ENSP00000450789
ENST00000554928
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005515 protein binding
Biological Process
GO:0006998 nuclear envelope organization
GO:0007097 nuclear migration
GO:0007163 establishment or maintenance of cell polarity
GO:0010761 fibroblast migration
GO:0030335 positive regulation of cell migration
GO:0031022 nuclear migration along microfilament
GO:0034504 protein localization to nucleus
GO:0051642 centrosome localization
GO:0090286 cytoskeletal anchoring at nuclear membrane
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005640 nuclear outer membrane
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005925 focal adhesion
GO:0016021 integral component of membrane
GO:0016235 aggresome
GO:0016529 sarcoplasmic reticulum
GO:0030016 myofibril
GO:0030018 Z disc
GO:0031258 lamellipodium membrane
GO:0031527 filopodium membrane
GO:0031965 nuclear membrane
GO:0031981 nuclear lumen
GO:0033017 sarcoplasmic reticulum membrane
GO:0034993 SUN-KASH complex
GO:0045111 intermediate filament cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063450
View Gene Order
ENSBTAG00000025450
Not yet available
Pathways
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.525392 Hs.739159 Hs.740777
RefSeq NM_015180 NM_182910 NM_182913 NM_182914 XM_005267454 XM_005267455 XM_005267456 XM_005267457 XM_005267458 XM_005267459 XM_006720084
HUGO
OMIM
CCDS CCDS41963 CCDS45124 CCDS45125 CCDS9761
HPRD 09763
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca