Version 5.4
Homo sapiens Gene: RAC1
Summary
InnateDB Gene IDBG-8115.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAC1
Gene Name ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Synonyms p21-Rac1; Rac-1; TC-25
Species Homo sapiens
Ensembl Gene ENSG00000136238
Encoded Proteins
IDBP-8117
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
IDBP-8119
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20167866
RAC1 cooperates with TLR2, MyD88, and PI3K in lipoteichoic acid-induced cPLA2/COX-2-dependent airway inflammatory responses.
InnateDB Annotation from Orthologs
Summary
PMID 25972472
[Mus musculus] Cd81 inhibits Rac1/Stat1 activation and negatively regulates the defence mechanisms to Listeria monocytogenes infection.
Entrez Gene
Summary The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:6374523-6403977
Strand Forward strand
Band p22.1
Transcripts
ENST00000356142 ENSP00000348461
ENST00000348035 ENSP00000258737
ENST00000488373
ENST00000497741
ENST00000473564
ENST00000495499
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 242 experimentally validated interaction(s) in this database.
They are also associated with 30 interaction(s) predicted by orthology.
Experimentally validated
Total 242 [view]
Protein-Protein 239 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 3 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 30 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0017137 Rab GTPase binding
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030742 GTP-dependent protein binding
GO:0031996 thioesterase binding
GO:0051022 Rho GDP-dissociation inhibitor binding
Biological Process
GO:0001934 positive regulation of protein phosphorylation
GO:0002093 auditory receptor cell morphogenesis
GO:0002551 mast cell chemotaxis
GO:0003382 epithelial cell morphogenesis
GO:0006184 GTP catabolic process
GO:0006897 endocytosis
GO:0006911 phagocytosis, engulfment
GO:0006928 cellular component movement
GO:0006935 chemotaxis
GO:0006954 inflammatory response
GO:0006972 hyperosmotic response
GO:0007010 cytoskeleton organization
GO:0007015 actin filament organization
GO:0007155 cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008283 cell proliferation
GO:0009611 response to wounding
GO:0009653 anatomical structure morphogenesis
GO:0010310 regulation of hydrogen peroxide metabolic process
GO:0010592 positive regulation of lamellipodium assembly
GO:0015031 protein transport
GO:0016032 viral process
GO:0016358 dendrite development
GO:0016477 cell migration
GO:0021799 cerebral cortex radially oriented cell migration
GO:0021831 embryonic olfactory bulb interneuron precursor migration
GO:0030032 lamellipodium assembly
GO:0030036 actin cytoskeleton organization
GO:0030041 actin filament polymerization
GO:0030168 platelet activation
GO:0030334 regulation of cell migration
GO:0030838 positive regulation of actin filament polymerization
GO:0031295 T cell costimulation
GO:0031529 ruffle organization
GO:0032707 negative regulation of interleukin-23 production
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035025 positive regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis
GO:0043065 positive regulation of apoptotic process
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043652 engulfment of apoptotic cell
GO:0045087 innate immune response (InnateDB)
GO:0045216 cell-cell junction organization
GO:0045453 bone resorption
GO:0045740 positive regulation of DNA replication
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0048532 anatomical structure arrangement
GO:0048813 dendrite morphogenesis
GO:0048870 cell motility
GO:0050690 regulation of defense response to virus by virus
GO:0051668 localization within membrane
GO:0060071 Wnt signaling pathway, planar cell polarity pathway
GO:0060263 regulation of respiratory burst
GO:0071526 semaphorin-plexin signaling pathway
GO:0071542 dopaminergic neuron differentiation
GO:0072659 protein localization to plasma membrane
GO:0090103 cochlea morphogenesis
GO:0097178 ruffle assembly
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0000139 Golgi membrane
GO:0001891 phagocytic cup
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005802 trans-Golgi network
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016023 cytoplasmic membrane-bounded vesicle
GO:0019897 extrinsic component of plasma membrane
GO:0030027 lamellipodium
GO:0031410 cytoplasmic vesicle
GO:0032587 ruffle membrane
GO:0036464 cytoplasmic ribonucleoprotein granule
GO:0042470 melanosome
GO:0042995 cell projection
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000001847
View Gene Order
Pathways
NETPATH
NetPath_1
Alpha6Beta4Integrin pathway
NetPath_4
EGFR1 pathway
NetPath_8
Wnt pathway
NetPath_18
IL6 pathway
NetPath_26
TWEAK pathway
REACTOME
REACT_147814
DAP12 signaling pathway
REACT_147694
DAP12 interactions pathway
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_19238
CD28 dependent Vav1 pathway pathway
REACT_19183
CD28 co-stimulation pathway
REACT_19344
Costimulation by the CD28 family pathway
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_1695
GPVI-mediated activation cascade pathway
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_11068
Nef and signal transduction pathway
REACT_147867
Translocation of GLUT4 to the plasma membrane pathway
REACT_25299
DSCAM interactions pathway
REACT_22272
Signal transduction by L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_22351
DCC mediated attractive signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_19266
Sema4D mediated inhibition of cell attachment and migration pathway
REACT_19277
Sema4D induced cell migration and growth-cone collapse pathway
REACT_19259
Sema4D in semaphorin signaling pathway
REACT_19236
Sema3A PAK dependent Axon repulsion pathway
REACT_19279
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion pathway
REACT_19226
Activation of Rac pathway
REACT_19342
Inactivation of Cdc42 and Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_172581
PCP/CE pathway pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_111155
Cell-Cell communication pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_19271
Semaphorin interactions pathway
REACT_228085
EPHB-mediated forward signaling pathway
REACT_11045
Signaling by Wnt pathway
REACT_12529
Signaling by VEGF pathway
REACT_14797
Signaling by GPCR pathway
REACT_6802
Innate Immune System pathway
REACT_798
Platelet activation, signaling and aggregation pathway
REACT_228016
VEGFR2 mediated vascular permeability pathway
REACT_18266
Axon guidance pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228226
Ephrin signaling pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_228189
EPH-ephrin mediated repulsion of cells pathway
REACT_6185
HIV Infection pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_6835
The role of Nef in HIV-1 replication and disease pathogenesis pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_116125
Disease pathway
REACT_163701
FCERI mediated MAPK activation pathway
REACT_604
Hemostasis pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04370
VEGF signaling pathway pathway
hsa04664
Fc epsilon RI signaling pathway pathway
hsa05210
Colorectal cancer pathway
hsa04310
Wnt signaling pathway pathway
hsa05120
Epithelial cell signaling in Helicobacter pylori infection pathway
hsa05211
Renal cell carcinoma pathway
hsa04010
MAPK signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04520
Adherens junction pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04662
B cell receptor signaling pathway pathway
hsa04510
Focal adhesion pathway
hsa04620
Toll-like receptor signaling pathway pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05212
Pancreatic cancer pathway
hsa05014
Amyotrophic lateral sclerosis (ALS) pathway
hsa04666
Fc gamma R-mediated phagocytosis pathway
hsa04722
Neurotrophin signaling pathway pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05416
Viral myocarditis pathway
hsa05100
Bacterial invasion of epithelial cells pathway
hsa04380
Osteoclast differentiation pathway
hsa04972
Pancreatic secretion pathway
hsa05131
Shigellosis pathway
hsa04145
Phagosome pathway
INOH
INOH website
CD4 T cell receptor signaling pathway
INOH website
Integrin signaling pathway pathway
INOH website
HGF signaling pathway pathway
PID NCI
nephrin_neph1_pathway
Nephrin/Neph1 signaling in the kidney podocyte
txa2pathway
Thromboxane A2 receptor signaling
ecadherin_nascentaj_pathway
E-cadherin signaling in the nascent adherens junction
met_pathway
Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
pi3kcipathway
Class I PI3K signaling events
s1p_s1p1_pathway
S1P1 pathway
rac1_reg_pathway
Regulation of RAC1 activity
lysophospholipid_pathway
LPA receptor mediated events
netrin_pathway
Netrin-mediated signaling events
avb3_integrin_pathway
Integrins in angiogenesis
s1p_s1p2_pathway
S1P2 pathway
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
erbb1_downstream_pathway
ErbB1 downstream signaling
integrin_a9b1_pathway
Alpha9 beta1 integrin signaling events
nectin_pathway
Nectin adhesion pathway
a6b1_a6b4_integrin_pathway
a6b1 and a6b4 Integrin signaling
fak_pathway
Signaling events mediated by focal adhesion kinase
ilk_pathway
Integrin-linked kinase signaling
ephbfwdpathway
EPHB forward signaling
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
p75ntrpathway
p75(NTR)-mediated signaling
arf_3pathway
Arf1 pathway
rac1_pathway
RAC1 signaling pathway
endothelinpathway
Endothelins
bcr_5pathway
BCR signaling pathway
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
ephrinbrevpathway
Ephrin B reverse signaling
prlsignalingeventspathway
Signaling events mediated by PRL
cdc42_pathway
CDC42 signaling events
s1p_s1p3_pathway
S1P3 pathway
syndecan_4_pathway
Syndecan-4-mediated signaling events
p38alphabetapathway
Regulation of p38-alpha and p38-beta
ret_pathway
Signaling events regulated by Ret tyrosine kinase
integrin_a4b1_pathway
Alpha4 beta1 integrin signaling events
arf6downstreampathway
Arf6 downstream pathway
wnt_noncanonical_pathway
Noncanonical Wnt signaling pathway
epha2_fwdpathway
EPHA2 forward signaling
lis1pathway
Lissencephaly gene (LIS1) in neuronal migration and development
ecadherin_keratinocyte_pathway
E-cadherin signaling in keratinocytes
il2_pi3kpathway
IL2 signaling events mediated by PI3K
pdgfrbpathway
PDGFR-beta signaling pathway
il6_7pathway
IL6-mediated signaling events
ncadherinpathway
N-cadherin signaling events
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
avb3_opn_pathway
Osteopontin-mediated events
p38_mkk3_6pathway
p38 MAPK signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.702986
RefSeq NM_006908 NM_018890
HUGO
OMIM
CCDS CCDS5348 CCDS5349
HPRD 03627
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca