Version 5.4
Homo sapiens Gene: USP25
Summary
InnateDB Gene IDBG-805.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol USP25
Gene Name ubiquitin specific peptidase 25
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000155313
Encoded Proteins
IDBP-807
ubiquitin specific peptidase 25
IDBP-809
ubiquitin specific peptidase 25
IDBP-811
ubiquitin specific peptidase 25
IDBP-228825
ubiquitin specific peptidase 25
IDBP-360720
ubiquitin specific peptidase 25
IDBP-360721
ubiquitin specific peptidase 25
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 26305951
[Mus musculus] Usp25 physically associates with Traf3 and Traf6 after infection by RNA or DNA viruses and promotes innate antiviral responses by protecting virus-induced proteasome-dependent or independent degradation of Traf3 and Traf6.
Entrez Gene
Summary Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:15730025-15880069
Strand Forward strand
Band q21.1
Transcripts
ENST00000285681 ENSP00000285681
ENST00000285679 ENSP00000285679
ENST00000351097 ENSP00000299574
ENST00000400183 ENSP00000383044
ENST00000453553 ENSP00000404086
ENST00000449491 ENSP00000402354
ENST00000464435
ENST00000478932
ENST00000547201
ENST00000549362
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
Experimentally validated
Total 40 [view]
Protein-Protein 40 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004843 ubiquitin-specific protease activity
GO:0005515 protein binding
GO:0008233 peptidase activity
GO:0032183 SUMO binding
GO:0036459 ubiquitinyl hydrolase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0070536 protein K63-linked deubiquitination
GO:0071108 protein K48-linked deubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022867
View Gene Order
ENSBTAG00000019314
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.728821
RefSeq NM_001283041 NM_001283042 NM_013396 XM_005260949 XM_006723992
HUGO
OMIM
CCDS CCDS33515 CCDS63336 CCDS63337
HPRD 05296
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca