Version 5.4
Homo sapiens Gene: SUN2
Summary
InnateDB Gene IDBG-7758.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SUN2
Gene Name Sad1 and UNC84 domain containing 2
Synonyms UNC84B
Species Homo sapiens
Ensembl Gene ENSG00000100242
Encoded Proteins
IDBP-293512
Sad1 and UNC84 domain containing 2
IDBP-293511
Sad1 and UNC84 domain containing 2
IDBP-293515
Sad1 and UNC84 domain containing 2
IDBP-376947
Sad1 and UNC84 domain containing 2
IDBP-376952
Sad1 and UNC84 domain containing 2
IDBP-376955
Sad1 and UNC84 domain containing 2
IDBP-376957
Sad1 and UNC84 domain containing 2
IDBP-376961
Sad1 and UNC84 domain containing 2
IDBP-376963
Sad1 and UNC84 domain containing 2
IDBP-376965
Sad1 and UNC84 domain containing 2
IDBP-376966
Sad1 and UNC84 domain containing 2
IDBP-376968
Sad1 and UNC84 domain containing 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a 'bridge' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
SUN1 (MIM 607723) and SUN2 are inner nuclear membrane (INM) proteins that play a major role in nuclear-cytoplasmic connection by formation of a \'bridge\' across the nuclear envelope, known as the LINC complex, via interaction with the conserved luminal KASH domain of nesprins (e.g., SYNE1; MIM 608441) located in the outer nuclear membrane (ONM). The LINC complex provides a direct connection between the nuclear lamina and the cytoskeleton, which contributes to nuclear positioning and cellular rigidity (summary by Haque et al., 2010 [PubMed 19933576]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:38734725-38794143
Strand Reverse strand
Band q13.1
Transcripts
ENST00000405510 ENSP00000385740
ENST00000405018 ENSP00000385616
ENST00000406622 ENSP00000383992
ENST00000455125 ENSP00000390154
ENST00000430185 ENSP00000403694
ENST00000438058 ENSP00000406941
ENST00000456894 ENSP00000415588
ENST00000420859 ENSP00000408834
ENST00000452294 ENSP00000414950
ENST00000433561 ENSP00000411615
ENST00000417332 ENSP00000412928
ENST00000439339 ENSP00000393271
ENST00000470642
ENST00000477262
ENST00000469086
ENST00000464202
ENST00000480307
ENST00000494273
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 24 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005521 lamin binding
GO:0008017 microtubule binding
GO:0042802 identical protein binding
Biological Process
GO:0006998 nuclear envelope organization
GO:0007052 mitotic spindle organization
GO:0007097 nuclear migration
GO:0030335 positive regulation of cell migration
GO:0031022 nuclear migration along microfilament
GO:0051642 centrosome localization
GO:0090286 cytoskeletal anchoring at nuclear membrane
GO:0090292 nuclear matrix anchoring at nuclear membrane
Cellular Component
GO:0000784 nuclear chromosome, telomeric region
GO:0000794 condensed nuclear chromosome
GO:0005635 nuclear envelope
GO:0005637 nuclear inner membrane
GO:0010008 endosome membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0034993 SUN-KASH complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042524
View Gene Order
ENSBTAG00000003693
Not yet available
Pathways
NETPATH
REACTOME
REACT_75792
Meiotic synapsis pathway
REACT_115566
Cell Cycle pathway
REACT_111183
Meiosis pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL B0QY66 B0QY68
UniProt Splice Variant
Entrez Gene 25777
UniGene Hs.517622 Hs.740137
RefSeq NM_001199579 NM_001199580 NM_015374 XM_005261500 XM_005261501
HUGO HGNC:14210
OMIM 613569
CCDS CCDS13978 CCDS56231
HPRD 15611
IMGT
EMBL AL008583 AL021707 AL021806
GenPept
RNA Seq Atlas 25777

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca