InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: LGALS3

Summary

InnateDB Gene

IDBG-7247.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

LGALS3

Gene Name

lectin, galactoside-binding, soluble, 3

Synonyms

CBP35; GAL3; GALBP; GALIG; L31; LGALS2; MAC2

Species

Homo sapiens

Ensembl Gene

ENSG00000131981

Encoded Proteins

IDBP-7249

lectin, galactoside-binding, soluble, 3

IDBP-599327

lectin, galactoside-binding, soluble, 3

IDBP-592580

lectin, galactoside-binding, soluble, 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 18825751

LGALS3 exerts a regulatory role in innate immunity by diminishing IL-1beta production and thus affecting resistance to Rhodococcus equi infection.

PMID 19951367

LGALS3, an abundant protein in macrophages and epithelial cells, belongs to a family of beta-galactoside-binding proteins, the galectins, with many proposed functions in immune response, development, differentiation, cancer and infection.

PMID 20208507

LGALS3 is part of the galectin family of proteins that have emerged as autonomous bacteria-killing agents, pointing to a principal role of these proteins in innate immunity.

PMID 22486577

LGALS3 influences the course of malaria in a Plasmodium species-specific manner. (Demonstrated in mice)

PMID 26589797

LGALS1 and LGALS3 play opposing roles in the inflammatory responses to Trichomonas vaginalis infection.

InnateDB Annotation from Orthologs

Summary

PMID 22486577

[Mus musculus] Lgals3 influences the course of malaria in a Plasmodium species-specific manner.

PMID 26857579

[Mus musculus] Lgals3 plays an important role in innate immunity to infection and colonization of Helicobacter pylori.

Entrez Gene

Summary

This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:55124110-55145413

Strand

Forward strand

Band

q22.3

Transcripts

ENST00000254301	ENSP00000254301
ENST00000553493	ENSP00000451526
ENST00000553755
ENST00000554715	ENSP00000451381
ENST00000556438
ENST00000556322
ENST00000556263

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 76 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	76 [view]
Protein-Protein	71 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019863	IgE binding
GO:0030246	carbohydrate binding
GO:0042056	chemoattractant activity
GO:0043236	laminin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0001501	skeletal system development
GO:0002548	monocyte chemotaxis
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0030855	epithelial cell differentiation
GO:0042129	regulation of T cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:0045806	negative regulation of endocytosis
GO:0048245	eosinophil chemotaxis
GO:0048246	macrophage chemotaxis
GO:0050860	negative regulation of T cell receptor signaling pathway
GO:0050918	positive chemotaxis
GO:0070232	regulation of T cell apoptotic process
GO:0071674	mononuclear cell migration
GO:0071677	positive regulation of mononuclear cell migration
GO:0090280	positive regulation of calcium ion import
GO:1902041	regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000521	negative regulation of immunological synapse formation
GO:2001189	negative regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0001772	immunological synapse
GO:0005578	proteinaceous extracellular matrix
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005681	spliceosomal complex
GO:0005737	cytoplasm
GO:0005743	mitochondrial inner membrane
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0016020	membrane
GO:0031012	extracellular matrix
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000050335

View Gene Order

ENSBTAG00000002326

Not yet available

Pathways

NETPATH

REACTOME

REACT_25195

Advanced glycosylation endproduct receptor signaling pathway

REACT_6802

Innate Immune System pathway

REACT_6900

Immune System pathway

KEGG

INOH

PID NCI

ras_pathway

Regulation of Ras family activation

hedgehog_glipathway

Hedgehog signaling events mediated by Gli proteins

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.531081 Hs.619784 Hs.734248

RefSeq

NM_002306

HUGO

OMIM

CCDS

CCDS41956

HPRD

17026

IMGT

EMBL

GenPept

RNA Seq Atlas