Version 5.4
Homo sapiens Gene: TYRO3
Summary
InnateDB Gene IDBG-7206.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TYRO3
Gene Name TYRO3 protein tyrosine kinase
Synonyms BYK; Dtk; RSE; Sky; Tif
Species Homo sapiens
Ensembl Gene ENSG00000092445
Encoded Proteins
IDBP-7208
TYRO3 protein tyrosine kinase
IDBP-586850
TYRO3 protein tyrosine kinase
IDBP-592296
TYRO3 protein tyrosine kinase
IDBP-590573
TYRO3 protein tyrosine kinase
IDBP-746959
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18083102
Tyrosine protein kinase that acts with AXL and MERTK as pleiotropic inhibitor of the innate immune response in DCs
InnateDB Annotation from Orthologs
Summary
PMID 23954153
[Mus musculus] Viruses engage Tyro3/Axl/Mertk (TAM) receptors in order to inhibit host type I IFN signalling.
Entrez Gene
Summary The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:41557675-41583586
Strand Forward strand
Band q15.1
Transcripts
ENST00000263798 ENSP00000263798
ENST00000559066 ENSP00000454050
ENST00000560992
ENST00000560227
ENST00000559815 ENSP00000453835
ENST00000560162
ENST00000559851 ENSP00000452995
ENST00000568343 ENSP00000455441
ENST00000568490
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004716 receptor signaling protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001779 natural killer cell differentiation
GO:0006468 protein phosphorylation
GO:0007155 cell adhesion
GO:0007165 signal transduction
GO:0007283 spermatogenesis
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021885 forebrain cell migration
GO:0023014 signal transduction by phosphorylation
GO:0030168 platelet activation
GO:0032940 secretion by cell
GO:0034122 negative regulation of toll-like receptor signaling pathway
GO:0034446 substrate adhesion-dependent cell spreading
GO:0042698 ovulation cycle
GO:0043277 apoptotic cell clearance
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0045824 negative regulation of innate immune response
GO:0046777 protein autophosphorylation
GO:0050728 negative regulation of inflammatory response
GO:0051250 negative regulation of lymphocyte activation
GO:0060068 vagina development
GO:0070050 neuron cellular homeostasis
GO:0070527 platelet aggregation
Cellular Component
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005789 endoplasmic reticulum membrane
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027298
View Gene Order
ENSBTAG00000001694
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 7301
UniGene Hs.381282
RefSeq NM_006293
HUGO HGNC:12446
OMIM 600341
CCDS CCDS10080
HPRD 02641
IMGT
EMBL
GenPept
RNA Seq Atlas 7301

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca