InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HBA2

Summary

InnateDB Gene

IDBG-7023.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HBA2

Gene Name

hemoglobin, alpha 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000188536

Encoded Proteins

IDBP-7025

hemoglobin, alpha 2

IDBP-234556

hemoglobin, alpha 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:172847-173710

Strand

Forward strand

Band

p13.3

Transcripts

ENST00000251595	ENSP00000251595
ENST00000397806	ENSP00000380908
ENST00000482565
ENST00000484216

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	16 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004601	peroxidase activity
GO:0005344	oxygen transporter activity
GO:0005506	iron ion binding
GO:0005515	protein binding
GO:0019825	oxygen binding
GO:0020037	heme binding
GO:0031720	haptoglobin binding

Biological Process

GO:0010942	positive regulation of cell death
GO:0015671	oxygen transport
GO:0015701	bicarbonate transport
GO:0042542	response to hydrogen peroxide
GO:0042744	hydrogen peroxide catabolic process
GO:0044281	small molecule metabolic process
GO:0051291	protein heterooligomerization
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005576	extracellular region
GO:0005829	cytosol
GO:0005833	hemoglobin complex
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0031838	haptoglobin-hemoglobin complex
GO:0070062	extracellular vesicular exosome
GO:0071682	endocytic vesicle lumen
GO:0072562	blood microparticle

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000069919

View Gene Order

ENSBTAG00000026417

Not yet available

Pathways

NETPATH

REACTOME

REACT_160163

Scavenging of heme from plasma pathway

REACT_121380

Erythrocytes take up oxygen and release carbon dioxide pathway

REACT_121329

Erythrocytes take up carbon dioxide and release oxygen pathway

REACT_120969

O2/CO2 exchange in erythrocytes pathway

REACT_160300

Binding and Uptake of Ligands by Scavenger Receptors pathway

REACT_111217

Metabolism pathway

KEGG

hsa05144

Malaria pathway

hsa05143

African trypanosomiasis pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_000517

HUGO

OMIM

CCDS

CCDS10398

HPRD

00785

IMGT

EMBL

GenPept

RNA Seq Atlas