Homo sapiens Gene: TRIOBP | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-6969.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | TRIOBP | ||||||||||||||||||
Gene Name | TRIO and F-actin binding protein | ||||||||||||||||||
Synonyms | DFNB28; dJ37E16.4; TAP68; TARA | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000100106 | ||||||||||||||||||
Encoded Proteins |
TRIO and F-actin binding protein
TRIO and F-actin binding protein
TRIO and F-actin binding protein
TRIO and F-actin binding protein
TRIO and F-actin binding protein
TRIO and F-actin binding protein
TRIO and F-actin binding protein
TRIO and F-actin binding protein
TRIO and F-actin binding protein
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
This gene encodes a protein with an N-terminal pleckstrin homology domain and a C-terminal coiled-coil region. The protein interacts with trio, which is involved with neural tissue development and controlling actin cytoskeleton organization, cell motility and cell growth. The protein also associates with F-actin and stabilizes F-actin structures. Mutations in this gene have been associated with a form of autosomal recessive nonsyndromic deafness. Multiple alternatively spliced transcript variants that would encode different isoforms have been found for this gene, however some transcripts may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Nov 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 22:37697004-37776556 | ||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||
Band | q13.1 | ||||||||||||||||||
Transcripts | |||||||||||||||||||
Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | |||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | |||||||||||||||||||
UniGene | Hs.533030 Hs.734724 | ||||||||||||||||||
RefSeq | NM_001039141 NM_007032 NM_138632 | ||||||||||||||||||
HUGO | |||||||||||||||||||
OMIM | |||||||||||||||||||
CCDS | CCDS33644 CCDS43015 CCDS43016 | ||||||||||||||||||
HPRD | 11028 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | |||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||