InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DLL4

Summary

InnateDB Gene

IDBG-6848.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DLL4

Gene Name

delta-like 4 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000128917

Encoded Proteins

IDBP-6850

delta-like 4 (Drosophila)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:40929340-40939072

Strand

Forward strand

Band

q15.1

Transcripts

ENST00000249749	ENSP00000249749
ENST00000557876
ENST00000559440

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005112	Notch binding
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001525	angiogenesis
GO:0001569	patterning of blood vessels
GO:0001974	blood vessel remodeling
GO:0003208	cardiac ventricle morphogenesis
GO:0003209	cardiac atrium morphogenesis
GO:0003222	ventricular trabecula myocardium morphogenesis
GO:0003344	pericardium morphogenesis
GO:0007154	cell communication
GO:0007165	signal transduction
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0007275	multicellular organismal development
GO:0007601	visual perception
GO:0008015	blood circulation
GO:0008285	negative regulation of cell proliferation
GO:0010596	negative regulation of endothelial cell migration
GO:0035912	dorsal aorta morphogenesis
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0044344	cellular response to fibroblast growth factor stimulus
GO:0050767	regulation of neurogenesis
GO:0060579	ventral spinal cord interneuron fate commitment
GO:0061074	regulation of neural retina development
GO:0061314	Notch signaling involved in heart development
GO:0072554	blood vessel lumenization
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis
GO:2000179	positive regulation of neural precursor cell proliferation