Version 5.4
Homo sapiens Gene: PTPRM
Summary
InnateDB Gene IDBG-670.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRM
Gene Name protein tyrosine phosphatase, receptor type, M
Synonyms hR-PTPu; PTPRL1; R-PTP-MU; RPTPM; RPTPU
Species Homo sapiens
Ensembl Gene ENSG00000173482
Encoded Proteins
IDBP-672
protein tyrosine phosphatase, receptor type, M
IDBP-229135
protein tyrosine phosphatase, receptor type, M
IDBP-229137
protein tyrosine phosphatase, receptor type, M
IDBP-727979
IDBP-726837
IDBP-727577
IDBP-725881
IDBP-727396
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP has been shown to mediate cell-cell aggregation through the interaction with another molecule of this PTP on an adjacent cell. This PTP can interact with scaffolding protein RACK1/GNB2L1, which may be necessary for the downstream signaling in response to cell-cell adhesion. Alternative splicing results in multiple transcripts encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:7566782-8406861
Strand Forward strand
Band p11.23
Transcripts
ENST00000332175 ENSP00000331418
ENST00000400060 ENSP00000382933
ENST00000400053 ENSP00000382927
ENST00000580949
ENST00000583153 ENSP00000462809
ENST00000580838
ENST00000577468 ENSP00000464128
ENST00000583289 ENSP00000462176
ENST00000578600
ENST00000577827
ENST00000578916 ENSP00000463558
ENST00000578571
ENST00000578698
ENST00000580170 ENSP00000463325
ENST00000578093
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 11 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005001 transmembrane receptor protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0016791 phosphatase activity
GO:0042802 identical protein binding
GO:0045296 cadherin binding
Biological Process
GO:0001937 negative regulation of endothelial cell proliferation
GO:0006470 protein dephosphorylation
GO:0007156 homophilic cell adhesion
GO:0007165 signal transduction
GO:0010596 negative regulation of endothelial cell migration
GO:0010842 retina layer formation
GO:0016311 dephosphorylation
GO:0016525 negative regulation of angiogenesis
GO:0031175 neuron projection development
GO:0031290 retinal ganglion cell axon guidance
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042493 response to drug
GO:0045909 positive regulation of vasodilation
Cellular Component
GO:0005737 cytoplasm
GO:0005887 integral component of plasma membrane
GO:0005911 cell-cell junction
GO:0005913 cell-cell adherens junction
GO:0016020 membrane
GO:0030027 lamellipodium
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033278
View Gene Order
ENSBTAG00000024015
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04520
Adherens junction pathway
INOH
PID NCI
nectin_pathway
Nectin adhesion pathway
Cross-References
SwissProt P28827
TrEMBL E7EPS8 Q49AC9
UniProt Splice Variant
Entrez Gene 5797
UniGene Hs.49774
RefSeq NM_002845 NM_001105244
HUGO HGNC:9675
OMIM 176888
CCDS CCDS11840 CCDS58613
HPRD 01479
IMGT
EMBL AC006566 AP000897 AP001091 AP001094 AP005118 AP005227 AP005900 BC040543 BC151842 CH471113 X58288
GenPept AAH40543 AAI51843 CAA41226 EAX01623 EAX01624
RNA Seq Atlas 5797

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca