InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: S100B

Summary

InnateDB Gene

IDBG-6570.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

S100B

Gene Name

S100 calcium binding protein B

Synonyms

NEF; S100; S100-B; S100beta

Species

Homo sapiens

Ensembl Gene

ENSG00000160307

Encoded Proteins

IDBP-6572

S100 calcium binding protein B

IDBP-98500

S100 calcium binding protein B

IDBP-234904

S100 calcium binding protein B

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer\'s disease, Down\'s syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:46598962-46605208

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000291700	ENSP00000291700
ENST00000367071	ENSP00000356038
ENST00000397648	ENSP00000380769

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.

Experimentally validated
Total	38 [view]
Protein-Protein	38 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0042802	identical protein binding
GO:0042803	protein homodimerization activity
GO:0044548	S100 protein binding
GO:0048156	tau protein binding
GO:0048306	calcium-dependent protein binding
GO:0050786	RAGE receptor binding

Biological Process

GO:0007409	axonogenesis
GO:0007417	central nervous system development
GO:0007611	learning or memory
GO:0007613	memory
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008360	regulation of cell shape
GO:0043065	positive regulation of apoptotic process
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response
GO:0048168	regulation of neuronal synaptic plasticity
GO:0048708	astrocyte differentiation
GO:0050806	positive regulation of synaptic transmission
GO:0051384	response to glucocorticoid
GO:0051597	response to methylmercury
GO:0060291	long-term synaptic potentiation
GO:0071456	cellular response to hypoxia
GO:2001015	negative regulation of skeletal muscle cell differentiation

Cellular Component

GO:0001726	ruffle
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0043025	neuronal cell body
GO:0043231	intracellular membrane-bounded organelle
GO:0048471	perinuclear region of cytoplasm