Version 5.4
Homo sapiens Gene: INTS1
Summary
InnateDB Gene IDBG-6535.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS1
Gene Name integrator complex subunit 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164880
Encoded Proteins
IDBP-292482
integrator complex subunit 1
IDBP-477741
integrator complex subunit 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary INTS1 is a subunit of the Integrator complex, which associates with the C-terminal domain of RNA polymerase II large subunit (POLR2A; MIM 180660) and mediates 3-prime end processing of small nuclear RNAs U1 (RNU1; MIM 180680) and U2 (RNU2; MIM 180690) (Baillat et al., 2005 [PubMed 16239144]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:1470277-1504367
Strand Reverse strand
Band p22.3
Transcripts
ENST00000404767 ENSP00000385722
ENST00000493446
ENST00000483196 ENSP00000419206
ENST00000479671
ENST00000482994
ENST00000468115
ENST00000496988
ENST00000493531
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 43 [view]
Protein-Protein 43 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
Biological Process
GO:0001832 blastocyst growth
GO:0001833 inner cell mass cell proliferation
GO:0016180 snRNA processing
GO:0034474 U2 snRNA 3'-end processing
GO:0043066 negative regulation of apoptotic process
GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031965 nuclear membrane
GO:0032039 integrator complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029547
View Gene Order
ENSBTAG00000000642
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.532188
RefSeq NM_001080453
HUGO
OMIM
CCDS CCDS47526
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca