InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAC2

Summary

InnateDB Gene

IDBG-6499.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAC2

Gene Name

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

Synonyms

EN-7; Gx; HSPC022; p21-Rac2

Species

Homo sapiens

Ensembl Gene

ENSG00000128340

Encoded Proteins

IDBP-6501

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

IDBP-293873

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

IDBP-293872

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

IDBP-293871

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

IDBP-375261

ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22018470

RAC2 is modified by Escherichia coli protein CNF1, which then interacts with the innate immune adaptors RIPK1 and RIPK2 to trigger an anti-bacterial immune response. This response was protective and increased the ability of the host to restrict pathogen growth, thus defining a mechanism of effector-triggered immunity that contributes to how metazoans defend against microbes with pathogenic potential.

InnateDB Annotation from Orthologs

Summary

PMID 22018470

[Mus musculus] Rac2 is modified by Escherichia coli protein CNF1 , which then interacts with the innate immune adaptors Ripk1 and Ripk2 to trigger an anti-bacterial immune response. This response was protective and increased the ability of the host to restrict pathogen growth, thus defining a mechanism of effector-triggered immunity that contributes to how metazoans defend against microbes with pathogenic potential. (Demonstrated in human)

Entrez Gene

Summary

The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. [provided by RefSeq, Jul 2008]
This gene encodes a member of the Ras superfamily of small guanosine triphosphate (GTP)-metabolizing proteins. The encoded protein localizes to the plasma membrane, where it regulates diverse processes, such as secretion, phagocytosis, and cell polarization. Activity of this protein is also involved in the generation of reactive oxygen species. Mutations in this gene are associated with neutrophil immunodeficiency syndrome. There is a pseudogene for this gene on chromosome 6. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:37225261-37244448

Strand

Reverse strand

Band

q13.1

Transcripts

ENST00000249071	ENSP00000249071
ENST00000405484	ENSP00000385590
ENST00000406508	ENSP00000385270
ENST00000401529	ENSP00000385666
ENST00000441619	ENSP00000403778
ENST00000481215
ENST00000469532

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 40 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	40 [view]
Protein-Protein	38 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005525	GTP binding

Biological Process

GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006913	nucleocytoplasmic transport
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0007411	axon guidance
GO:0007596	blood coagulation
GO:0008284	positive regulation of cell proliferation
GO:0010310	regulation of hydrogen peroxide metabolic process
GO:0015031	protein transport
GO:0030031	cell projection assembly
GO:0030036	actin cytoskeleton organization
GO:0030168	platelet activation
GO:0045087	innate immune response (InnateDB)
GO:0045453	bone resorption
GO:0051056	regulation of small GTPase mediated signal transduction
GO:0060263	regulation of respiratory burst

Cellular Component

GO:0005622	intracellular
GO:0005635	nuclear envelope
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome