Homo sapiens Gene: IL2RB | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-6418.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | IL2RB | ||||||||||||||||||||||
Gene Name | interleukin 2 receptor, beta | ||||||||||||||||||||||
Synonyms | CD122; IL15RB; P70-75 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000100385 | ||||||||||||||||||||||
Encoded Proteins |
interleukin 2 receptor, beta
interleukin 2 receptor, beta
interleukin 2 receptor, beta
interleukin 2 receptor, beta
interleukin 2 receptor, beta
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
IL2RB is phosphorylated by JAK1and different IL2RB tyrosines couple to at least two signalling pathways (JAK-STAT and SHC-coupled) and synergistically mediate IL2-induced proliferation.
IL2RB physically associates with JAK1 suggesting that regulation of JAK1 may be linked to IL2 induced signal transduction.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Mus musculus] Selective loss of the histone-lysine N-methyltransferase Ezh2 (enhancer of zeste homolog 2) or inhibition of its enzymatic activity increases generation of the Il2rb (CD122) natural killer (NK) precursors and mature NK progeny.
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Entrez Gene | |||||||||||||||||||||||
Summary |
The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 22:37125838-37175054 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q12.3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
IL2 pathway
IL5 pathway
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REACTOME |
Interleukin receptor SHC signaling pathway
Interleukin-3, 5 and GM-CSF signaling pathway
Interleukin-2 signaling pathway
GPVI-mediated activation cascade pathway
G beta:gamma signalling through PI3Kgamma pathway
Cytokine Signaling in Immune system pathway
Signaling by GPCR pathway
Platelet activation, signaling and aggregation pathway
G-protein beta:gamma signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
Immune System pathway
Signaling by Interleukins pathway
Hemostasis pathway
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KEGG |
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
Endocytosis pathway
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INOH |
JAK STAT pathway and regulation pathway
IL-2 signaling pathway
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PID NCI |
IL2-mediated signaling events
Downstream signaling in naïve CD8+ T cells
IL12-mediated signaling events
SHP2 signaling
IL2 signaling events mediated by STAT5
IL2 signaling events mediated by PI3K
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | B0QYC0 B0QYC1 B0QYC2 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 3560 | ||||||||||||||||||||||
UniGene | Hs.474787 | ||||||||||||||||||||||
RefSeq | NM_000878 | ||||||||||||||||||||||
HUGO | HGNC:6009 | ||||||||||||||||||||||
OMIM | 146710 | ||||||||||||||||||||||
CCDS | CCDS13942 | ||||||||||||||||||||||
HPRD | 00896 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AL022314 Z82188 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 3560 | ||||||||||||||||||||||