Homo sapiens Gene: FGFRL1 | |||||||||||||
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Summary | |||||||||||||
InnateDB Gene | IDBG-6367.6 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | FGFRL1 | ||||||||||||
Gene Name | fibroblast growth factor receptor-like 1 | ||||||||||||
Synonyms | |||||||||||||
Species | Homo sapiens | ||||||||||||
Ensembl Gene | ENSG00000127418 | ||||||||||||
Encoded Proteins |
fibroblast growth factor receptor-like 1
fibroblast growth factor receptor-like 1
fibroblast growth factor receptor-like 1
fibroblast growth factor receptor-like 1
fibroblast growth factor receptor-like 1
fibroblast growth factor receptor-like 1
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Protein Structure | |||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||
Entrez Gene | |||||||||||||
Summary |
The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. A marked difference between this gene product and the other family members is its lack of a cytoplasmic tyrosine kinase domain. The result is a transmembrane receptor that could interact with other family members and potentially inhibit signaling. Multiple alternatively spliced transcript variants encoding the same isoform have been found for this gene. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||
Type | Protein coding | ||||||||||||
Genomic Location | Chromosome 4:1009936-1026897 | ||||||||||||
Strand | Forward strand | ||||||||||||
Band | p16.3 | ||||||||||||
Transcripts | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Cross-References | |||||||||||||
SwissProt | |||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | |||||||||||||
UniGene | Hs.628675 | ||||||||||||
RefSeq | NM_001004356 NM_001004358 NM_021923 | ||||||||||||
HUGO | |||||||||||||
OMIM | |||||||||||||
CCDS | CCDS3344 | ||||||||||||
HPRD | 16163 | ||||||||||||
IMGT | |||||||||||||
EMBL | |||||||||||||
GenPept | |||||||||||||
RNA Seq Atlas | |||||||||||||