InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MCM3AP

Summary

InnateDB Gene

IDBG-6351.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM3AP

Gene Name

minichromosome maintenance complex component 3 associated protein

Synonyms

GANP; MAP80; SAC3

Species

Homo sapiens

Ensembl Gene

ENSG00000160294

Encoded Proteins

IDBP-6353

minichromosome maintenance complex component 3 associated protein

IDBP-234727

minichromosome maintenance complex component 3 associated protein

IDBP-371700

minichromosome maintenance complex component 3 associated protein

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. [provided by RefSeq, Jul 2008]
The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. [provided by RefSeq, Jan 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:46235126-46286297

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000291688	ENSP00000291688
ENST00000397708	ENSP00000380820
ENST00000426537	ENSP00000408934
ENST00000486937
ENST00000496607
ENST00000467026
ENST00000481113
ENST00000494755
ENST00000479557
ENST00000495475

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 35 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	35 [view]
Protein-Protein	35 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0016746	transferase activity, transferring acyl groups

Biological Process

GO:0002376	immune system process
GO:0006260	DNA replication
GO:0006606	protein import into nucleus
GO:0051028	mRNA transport

Cellular Component

GO:0005634	nucleus
GO:0005643	nuclear pore
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000001150

View Gene Order

ENSBTAG00000003148

Not yet available

Cross-References

SwissProt

O60318

TrEMBL

B3KWZ4 N0GVG8

UniProt Splice Variant

Entrez Gene

8888

UniGene

Hs.389037 Hs.592438 Hs.678090

RefSeq

XM_005261203 XM_005261204 XM_005261205 XM_005261206 XM_006724064 XM_006724065 NM_003906

HUGO

HGNC:6946

OMIM

603294

CCDS

CCDS13734

HPRD

04483

IMGT

EMBL

AB005543 AB011144 AJ010089 AK126313 AP000471 AP001469 AY590469 BC004497 BC013285 BC104958 BC104960 HF584748

GenPept

AAH04497 AAH13285 AAI04959 AAI04961 AAS89300 BAA25170 BAA25498 BAG54306 CAB52687 CCQ44045

RNA Seq Atlas

8888