InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CSF2RB

Summary

InnateDB Gene

IDBG-6178.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSF2RB

Gene Name

colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)

Synonyms

CD131; CDw131; IL3RB; IL5RB; SMDP5

Species

Homo sapiens

Ensembl Gene

ENSG00000100368

Encoded Proteins

IDBP-6180

colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)

IDBP-293938

colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)

IDBP-293939

colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)

IDBP-375016

colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 15988755

CSF2RB (IL3RB) is tyrosine phosphorylated by the simultaneous activation of both JAK1 and JAK2 fusion proteins, but not either one alone. Phosphorylated CSF2RB then induces the activation of downstream signaling molecules, including STAT5, AKT, and MAPK, and the conferring of factor-independent growth to IL-3-dependent Ba/F3 cells

Entrez Gene

Summary

The protein encoded by this gene is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this gene have been reported to be associated with protein alveolar proteinosis (PAP). [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:36913628-36940449

Strand

Forward strand

Band

q12.3

Transcripts

ENST00000262825	ENSP00000262825
ENST00000403662	ENSP00000384053
ENST00000406230	ENSP00000385271
ENST00000421539	ENSP00000393585

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 49 experimentally validated interaction(s) in this database.

Experimentally validated
Total	49 [view]
Protein-Protein	44 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0004896	cytokine receptor activity
GO:0004912	interleukin-3 receptor activity
GO:0004914	interleukin-5 receptor activity
GO:0005515	protein binding

Biological Process

GO:0007165	signal transduction
GO:0007585	respiratory gaseous exchange
GO:0019221	cytokine-mediated signaling pathway
GO:0032496	response to lipopolysaccharide
GO:0036016	cellular response to interleukin-3
GO:0038043	interleukin-5-mediated signaling pathway
GO:0038156	interleukin-3-mediated signaling pathway
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0030526	granulocyte macrophage colony-stimulating factor receptor complex