InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BUB1B

Summary

InnateDB Gene

IDBG-6103.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BUB1B

Gene Name

budding uninhibited by benzimidazoles 1 homolog beta (yeast)

Synonyms

Bub1A; BUB1beta; BUBR1; hBUBR1; MAD3L; MVA1; SSK1

Species

Homo sapiens

Ensembl Gene

ENSG00000156970

Encoded Proteins

IDBP-6105

budding uninhibited by benzimidazoles 1 homolog beta (yeast)

IDBP-365778

budding uninhibited by benzimidazoles 1 homolog beta (yeast)

IDBP-596565

budding uninhibited by benzimidazoles 1 homolog beta (yeast)

IDBP-587258

budding uninhibited by benzimidazoles 1 homolog beta (yeast)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:40161023-40221136

Strand

Forward strand

Band

q15.1

Transcripts

ENST00000287598	ENSP00000287598
ENST00000412359	ENSP00000398470
ENST00000560120
ENST00000559414
ENST00000558715	ENSP00000453861
ENST00000559733	ENSP00000453643
ENST00000559461
ENST00000557848
ENST00000559772
ENST00000558972
ENST00000558151

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 118 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	118 [view]
Protein-Protein	115 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000278	mitotic cell cycle
GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007049	cell cycle
GO:0007051	spindle organization
GO:0007067	mitotic nuclear division
GO:0007091	metaphase/anaphase transition of mitotic cell cycle
GO:0007093	mitotic cell cycle checkpoint
GO:0007094	mitotic spindle assembly checkpoint
GO:0008283	cell proliferation
GO:0031145	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034501	protein localization to kinetochore
GO:0048015	phosphatidylinositol-mediated signaling
GO:0051436	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0071459	protein localization to chromosome, centromeric region

Cellular Component

GO:0000776	kinetochore
GO:0000777	condensed chromosome kinetochore
GO:0000778	condensed nuclear chromosome kinetochore
GO:0000940	condensed chromosome outer kinetochore
GO:0005680	anaphase-promoting complex
GO:0005737	cytoplasm
GO:0005815	microtubule organizing center
GO:0005829	cytosol
GO:0048471	perinuclear region of cytoplasm
GO:0051233	spindle midzone