Version 5.4
Homo sapiens Gene: MAP4K5
Summary
InnateDB Gene IDBG-6029.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP4K5
Gene Name mitogen-activated protein kinase kinase kinase kinase 5
Synonyms GCKR; KHS; KHS1; MAPKKKK5
Species Homo sapiens
Ensembl Gene ENSG00000012983
Encoded Proteins
IDBP-6031
mitogen-activated protein kinase kinase kinase kinase 5
IDBP-588222
mitogen-activated protein kinase kinase kinase kinase 5
IDBP-585426
mitogen-activated protein kinase kinase kinase kinase 5
IDBP-593336
mitogen-activated protein kinase kinase kinase kinase 5
IDBP-601724
mitogen-activated protein kinase kinase kinase kinase 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:50418501-50561126
Strand Reverse strand
Band q22.1
Transcripts
ENST00000013125 ENSP00000013125
ENST00000554990
ENST00000557124
ENST00000557210
ENST00000554091 ENSP00000451926
ENST00000557578
ENST00000555216 ENSP00000452289
ENST00000557390 ENSP00000451980
ENST00000554066
ENST00000554273 ENSP00000451452
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 12 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005083 small GTPase regulator activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0000165 MAPK cascade
GO:0000185 activation of MAPKKK activity
GO:0006468 protein phosphorylation
GO:0007257 activation of JUN kinase activity
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034761
View Gene Order
ENSBTAG00000014792
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.130491
RefSeq NM_006575 NM_198794 XM_006720013
HUGO
OMIM
CCDS
HPRD 05374
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca