Version 5.4
Homo sapiens Gene: EIF2AK4
Summary
InnateDB Gene IDBG-5997.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF2AK4
Gene Name eukaryotic translation initiation factor 2 alpha kinase 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000128829
Encoded Proteins
IDBP-5999
eukaryotic translation initiation factor 2 alpha kinase 4
IDBP-602020
eukaryotic translation initiation factor 2 alpha kinase 4
IDBP-587326
eukaryotic translation initiation factor 2 alpha kinase 4
IDBP-592222
eukaryotic translation initiation factor 2 alpha kinase 4
IDBP-583456
eukaryotic translation initiation factor 2 alpha kinase 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary EIF2AK4 belongs to a family of kinases that phosphorylate the alpha subunit of eukaryotic translation initiation factor-2 (EIF2S1; MIM 603907) to downregulate protein synthesis in response to varied cellular stresses (Berlanga et al., 1999 [PubMed 10504407]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:39934146-40035591
Strand Forward strand
Band q15.1
Transcripts
ENST00000263791 ENSP00000263791
ENST00000559624 ENSP00000453148
ENST00000560648 ENSP00000453968
ENST00000560855 ENSP00000453575
ENST00000558629
ENST00000559311
ENST00000558557
ENST00000558743
ENST00000559032
ENST00000558823 ENSP00000454210
ENST00000624709
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0042803 protein homodimerization activity
Biological Process
GO:0006446 regulation of translational initiation
GO:0006468 protein phosphorylation
GO:0009267 cellular response to starvation
GO:0017148 negative regulation of translation
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0043558 regulation of translational initiation in response to stress
Cellular Component
GO:0022626 cytosolic ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005102
View Gene Order
ENSBTAG00000014351
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
hsa05160
Hepatitis C pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603613 Hs.656673
RefSeq NM_001013703 XM_005254393
HUGO
OMIM
CCDS CCDS42016
HPRD 18447
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca