InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: THBS1

Summary

InnateDB Gene

IDBG-5926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

THBS1

Gene Name

thrombospondin 1

Synonyms

THBS; THBS-1; TSP; TSP-1; TSP1

Species

Homo sapiens

Ensembl Gene

ENSG00000137801

Encoded Proteins

IDBP-5928

thrombospondin 1

IDBP-235021

thrombospondin 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21573017

THBS1 expression is associated with decreased phagocytosis and bacterial clearance, resulting in increased peritoneal inflammation and mortality from sepsis. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 21573017

[Mus musculus] Thbs1 expression is associated with decreased phagocytosis and bacterial clearance, resulting in increased peritoneal inflammation and mortality from sepsis.

Entrez Gene

Summary

The protein encoded by this gene is a subunit of a disulfide-linked homotrimeric protein. This protein is an adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions. This protein can bind to fibrinogen, fibronectin, laminin, type V collagen and integrins alpha-V/beta-1. This protein has been shown to play roles in platelet aggregation, angiogenesis, and tumorigenesis. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:39581079-39599466

Strand

Forward strand

Band

q14

Transcripts

ENST00000260356	ENSP00000260356
ENST00000397591	ENSP00000380720
ENST00000478845
ENST00000497720
ENST00000466755
ENST00000490247
ENST00000484734
ENST00000560894
ENST00000559746

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 44 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	44 [view]
Protein-Protein	42 [view]
Protein-DNA	1 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001786	phosphatidylserine binding
GO:0001948	glycoprotein binding
GO:0001968	fibronectin binding
GO:0005178	integrin binding
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0017134	fibroblast growth factor binding
GO:0030169	low-density lipoprotein particle binding
GO:0042802	identical protein binding
GO:0043236	laminin binding
GO:0043394	proteoglycan binding
GO:0050431	transforming growth factor beta binding
GO:0050840	extracellular matrix binding
GO:0070051	fibrinogen binding
GO:0070052	collagen V binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0001666	response to hypoxia
GO:0001937	negative regulation of endothelial cell proliferation
GO:0001953	negative regulation of cell-matrix adhesion
GO:0002040	sprouting angiogenesis
GO:0002544	chronic inflammatory response
GO:0002576	platelet degranulation
GO:0002581	negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0002605	negative regulation of dendritic cell antigen processing and presentation
GO:0003151	outflow tract morphogenesis
GO:0003197	endocardial cushion development
GO:0003417	growth plate cartilage development
GO:0006954	inflammatory response
GO:0006955	immune response
GO:0006986	response to unfolded protein
GO:0007050	cell cycle arrest
GO:0007155	cell adhesion
GO:0007596	blood coagulation
GO:0009612	response to mechanical stimulus
GO:0009749	response to glucose
GO:0010595	positive regulation of endothelial cell migration
GO:0010596	negative regulation of endothelial cell migration
GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport
GO:0010751	negative regulation of nitric oxide mediated signal transduction
GO:0010754	negative regulation of cGMP-mediated signaling
GO:0010757	negative regulation of plasminogen activation
GO:0010759	positive regulation of macrophage chemotaxis
GO:0010763	positive regulation of fibroblast migration
GO:0010811	positive regulation of cell-substrate adhesion
GO:0016477	cell migration
GO:0016525	negative regulation of angiogenesis
GO:0018149	peptide cross-linking
GO:0030168	platelet activation
GO:0030194	positive regulation of blood coagulation
GO:0030198	extracellular matrix organization
GO:0030335	positive regulation of cell migration
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0032026	response to magnesium ion
GO:0032570	response to progesterone
GO:0032695	negative regulation of interleukin-12 production
GO:0032914	positive regulation of transforming growth factor beta1 production
GO:0033574	response to testosterone
GO:0034605	cellular response to heat
GO:0034976	response to endoplasmic reticulum stress
GO:0040037	negative regulation of fibroblast growth factor receptor signaling pathway
GO:0042327	positive regulation of phosphorylation
GO:0042493	response to drug
GO:0042535	positive regulation of tumor necrosis factor biosynthetic process
GO:0043032	positive regulation of macrophage activation
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0043537	negative regulation of blood vessel endothelial cell migration
GO:0043652	engulfment of apoptotic cell
GO:0045087	innate immune response (InnateDB)
GO:0045727	positive regulation of translation
GO:0045766	positive regulation of angiogenesis
GO:0048266	behavioral response to pain
GO:0048514	blood vessel morphogenesis
GO:0050921	positive regulation of chemotaxis
GO:0051592	response to calcium ion
GO:0051895	negative regulation of focal adhesion assembly
GO:0051897	positive regulation of protein kinase B signaling
GO:0051918	negative regulation of fibrinolysis
GO:0071356	cellular response to tumor necrosis factor
GO:0071363	cellular response to growth factor stimulus
GO:0071636	positive regulation of transforming growth factor beta production
GO:1902043	positive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000353	positive regulation of endothelial cell apoptotic process
GO:2000379	positive regulation of reactive oxygen species metabolic process
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005577	fibrinogen complex
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016529	sarcoplasmic reticulum
GO:0030141	secretory granule
GO:0031012	extracellular matrix
GO:0031091	platelet alpha granule
GO:0031093	platelet alpha granule lumen
GO:0070062	extracellular vesicular exosome