InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MYH9

Summary

InnateDB Gene

IDBG-5777.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MYH9

Gene Name

myosin, heavy chain 9, non-muscle

Synonyms

BDPLT6; DFNA17; EPSTS; FTNS; MHA; NMHC-II-A; NMMHC-IIA; NMMHCA

Species

Homo sapiens

Ensembl Gene

ENSG00000100345

Encoded Proteins

IDBP-5779

myosin, heavy chain 9, non-muscle

IDBP-294020

myosin, heavy chain 9, non-muscle

IDBP-374707

myosin, heavy chain 9, non-muscle

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 24489676

The calpain-MYH9-RAB7B axis regulates TLR4 containing alpha-granules trafficking in thrombin-stimulated platelets.

Entrez Gene

Summary

This gene encodes a conventional non-muscle myosin; this protein should not be confused with the unconventional myosin-9a or 9b (MYO9A or MYO9B). The encoded protein is a myosin IIA heavy chain that contains an IQ domain and a myosin head-like domain which is involved in several important functions, including cytokinesis, cell motility and maintenance of cell shape. Defects in this gene have been associated with non-syndromic sensorineural deafness autosomal dominant type 17, Epstein syndrome, Alport syndrome with macrothrombocytopenia, Sebastian syndrome, Fechtner syndrome and macrothrombocytopenia with progressive sensorineural deafness. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:36281281-36388018

Strand

Reverse strand

Band

q12.3

Transcripts

ENST00000216181	ENSP00000216181
ENST00000401701	ENSP00000384631
ENST00000456729	ENSP00000414852
ENST00000475726
ENST00000486218
ENST00000459960
ENST00000495928
ENST00000473022
ENST00000477189
ENST00000472210
ENST00000463027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 135 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	135 [view]
Protein-Protein	133 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000146	microfilament motor activity
GO:0000166	nucleotide binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003774	motor activity
GO:0003779	actin binding
GO:0004871	signal transducer activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0016887	ATPase activity
GO:0030898	actin-dependent ATPase activity
GO:0042803	protein homodimerization activity
GO:0043495	protein anchor
GO:0043531	ADP binding
GO:0044822	poly(A) RNA binding
GO:0051015	actin filament binding

Biological Process

GO:0000212	meiotic spindle organization
GO:0000904	cell morphogenesis involved in differentiation
GO:0000910	cytokinesis
GO:0001525	angiogenesis
GO:0001701	in utero embryonic development
GO:0001768	establishment of T cell polarity
GO:0006200	ATP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006509	membrane protein ectodomain proteolysis
GO:0006928	cellular component movement
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0007229	integrin-mediated signaling pathway
GO:0007411	axon guidance
GO:0007520	myoblast fusion
GO:0008152	metabolic process
GO:0008360	regulation of cell shape
GO:0015031	protein transport
GO:0016337	single organismal cell-cell adhesion
GO:0030048	actin filament-based movement
GO:0030220	platelet formation
GO:0030224	monocyte differentiation
GO:0031032	actomyosin structure organization
GO:0031532	actin cytoskeleton reorganization
GO:0032796	uropod organization
GO:0038032	termination of G-protein coupled receptor signaling pathway
GO:0043534	blood vessel endothelial cell migration
GO:0045087	innate immune response (InnateDB)
GO:0050900	leukocyte migration
GO:0051295	establishment of meiotic spindle localization

Cellular Component

GO:0001725	stress fiber
GO:0001726	ruffle
GO:0001772	immunological synapse
GO:0001931	uropod
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005826	actomyosin contractile ring
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005913	cell-cell adherens junction
GO:0005938	cell cortex
GO:0008180	COP9 signalosome
GO:0008305	integrin complex
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016459	myosin complex
GO:0016460	myosin II complex
GO:0030863	cortical cytoskeleton
GO:0031252	cell leading edge
GO:0031594	neuromuscular junction
GO:0032154	cleavage furrow
GO:0042641	actomyosin
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome
GO:0097513	myosin II filament