Version 5.4
Homo sapiens Gene: ITGB2
Summary
InnateDB Gene IDBG-5590.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITGB2
Gene Name integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Synonyms CD18; LAD; LCAMB; LFA-1; MAC-1; MF17; MFI7
Species Homo sapiens
Ensembl Gene ENSG00000160255
Encoded Proteins
IDBP-5592
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-5594
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-5596
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-234403
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-234405
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-234407
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-234409
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-234411
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-480180
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-484203
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-474595
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-483125
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-473821
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-477945
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-483496
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-481263
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-475919
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
IDBP-812571
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21245270
ITGAM :: ITGB2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by ITGAM :: ITGB2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection. (Demonstrated in murine model)
PMID 22396536
ITGB2 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs.
PMID 22844116
ITGAX::ITGB2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.
InnateDB Annotation from Orthologs
Summary
PMID 21245270
[Mus musculus] Itgam :: Itgb2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by Itgam :: Itgb2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection.
PMID 22396536
[Mus musculus] Itgb2 is involved in cell-cell contact signalling between activated apoptotic lymphocytes and dendritic cells (DC) during the maturation of DCs. (Demonstrated in human)
PMID 22844116
[Mus musculus] Itgax::Itgb2 is a leukocyte receptor for Candida albicans and is essential for protection against fungal infections.
Entrez Gene
Summary The product of this gene belongs to the integrin beta chain family of proteins. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. This gene encodes the integrin beta chain beta 2. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:44885953-44931989
Strand Reverse strand
Band q22.3
Transcripts
ENST00000355153 ENSP00000347279
ENST00000302347 ENSP00000303242
ENST00000320216 ENSP00000317697
ENST00000397857 ENSP00000380955
ENST00000397854 ENSP00000380952
ENST00000397852 ENSP00000380950
ENST00000397850 ENSP00000380948
ENST00000397846 ENSP00000380944
ENST00000475170
ENST00000498666
ENST00000523323 ENSP00000427732
ENST00000479202
ENST00000521987
ENST00000523663 ENSP00000428503
ENST00000522931 ENSP00000428979
ENST00000517563 ENSP00000428413
ENST00000522688 ENSP00000428125
ENST00000520389 ENSP00000428434
ENST00000524251 ENSP00000430901
ENST00000517819 ENSP00000428870
ENST00000479849
ENST00000523126
ENST00000521995 ENSP00000429683
ENST00000518033
ENST00000610622 ENSP00000480700
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 66 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 66 [view]
Protein-Protein 66 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0004872 receptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0046872 metal ion binding
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0007155 cell adhesion
GO:0007159 leukocyte cell-cell adhesion
GO:0007160 cell-matrix adhesion
GO:0007229 integrin-mediated signaling pathway
GO:0007267 cell-cell signaling
GO:0007275 multicellular organismal development
GO:0007596 blood coagulation
GO:0008360 regulation of cell shape
GO:0030198 extracellular matrix organization
GO:0030593 neutrophil chemotaxis
GO:0034142 toll-like receptor 4 signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0050776 regulation of immune response
GO:0050900 leukocyte migration
Cellular Component
GO:0005886 plasma membrane
GO:0008305 integrin complex
GO:0009986 cell surface
GO:0016020 membrane
GO:0043235 receptor complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000290
View Gene Order
ENSBTAG00000017060
Not yet available
Pathways
NETPATH
REACTOME
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_12051
Cell surface interactions at the vascular wall pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_6802
Innate Immune System pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_604
Hemostasis pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04670
Leukocyte transendothelial migration pathway
hsa04650
Natural killer cell mediated cytotoxicity pathway
hsa05416
Viral myocarditis pathway
hsa05140
Leishmaniasis pathway
hsa05150
Staphylococcus aureus infection pathway
hsa05146
Amoebiasis pathway
hsa05144
Malaria pathway
hsa04145
Phagosome pathway
INOH
INOH website
Integrin signaling pathway pathway
PID NCI
integrin_cs_pathway
Integrin family cell surface interactions
integrin2_pathway
Beta2 integrin cell surface interactions
upa_upar_pathway
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
hif1_tfpathway
HIF-1-alpha transcription factor network
amb2_neutrophils_pathway
amb2 Integrin signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.375957
RefSeq NM_000211 NM_001127491 XM_006724001
HUGO
OMIM
CCDS CCDS13716
HPRD 02506
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca