Homo sapiens Gene: NFATC1 | |||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||||||||||||||||||||
InnateDB Gene | IDBG-5452.6 | ||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||
Gene Symbol | NFATC1 | ||||||||||||||||||||||||||
Gene Name | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 | ||||||||||||||||||||||||||
Synonyms | NF-ATC; NFAT2; NFATc | ||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||
Ensembl Gene | ENSG00000131196 | ||||||||||||||||||||||||||
Encoded Proteins |
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
|
||||||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||
Summary |
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2008] The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013] |
||||||||||||||||||||||||||
Gene Information | |||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||
Genomic Location | Chromosome 18:79395856-79529325 | ||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||
Band | q23 | ||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.
|
||||||||||||||||||||||||||
Gene Ontology | |||||||||||||||||||||||||||
Molecular Function |
|
||||||||||||||||||||||||||
Biological Process |
|
||||||||||||||||||||||||||
Cellular Component |
|
||||||||||||||||||||||||||
Orthologs | |||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
|
Gene ID
Gene Order
Not yet available
|
||||||||||||||||||||||||||
Pathways | |||||||||||||||||||||||||||
NETPATH |
TCR pathway
RANKL pathway
|
||||||||||||||||||||||||||
REACTOME |
Ca2+ pathway pathway
beta-catenin independent WNT signaling pathway
Signaling by Wnt pathway
Innate Immune System pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
Immune System pathway
FCERI mediated Ca+2 mobilization pathway
|
||||||||||||||||||||||||||
KEGG |
Wnt signaling pathway pathway
MAPK signaling pathway pathway
B cell receptor signaling pathway pathway
T cell receptor signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Osteoclast differentiation pathway
|
||||||||||||||||||||||||||
INOH | |||||||||||||||||||||||||||
PID NCI |
Downstream signaling in naïve CD8+ T cells
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
Glucocorticoid receptor regulatory network
BCR signaling pathway
Role of Calcineurin-dependent NFAT signaling in lymphocytes
|
||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||
SwissProt | O95644 | ||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||
Entrez Gene | 4772 | ||||||||||||||||||||||||||
UniGene | Hs.534074 Hs.739976 | ||||||||||||||||||||||||||
RefSeq | NM_172388 NM_001278669 NM_001278670 NM_001278672 NM_001278673 NM_001278675 NM_006162 NM_172387 NM_172389 NM_172390 XM_006722477 XM_006722478 | ||||||||||||||||||||||||||
HUGO | HGNC:7775 | ||||||||||||||||||||||||||
OMIM | 600489 | ||||||||||||||||||||||||||
CCDS | CCDS12016 CCDS12015 CCDS32850 CCDS59326 CCDS59327 CCDS62467 CCDS62468 CCDS62469 CCDS62470 CCDS62471 | ||||||||||||||||||||||||||
HPRD | 02729 | ||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||
EMBL | AC018445 AC023090 BC104753 BC112243 CH471117 EU887559 EU887560 EU887561 EU887562 EU887563 EU887564 EU887565 EU887566 U08015 U59736 U80917 U80918 U80919 | ||||||||||||||||||||||||||
GenPept | AAA19601 AAC50869 AAD00450 AAD00451 AAD00452 AAI04754 AAI12244 ACG55579 ACG55580 ACG55581 ACG55582 ACG55583 ACG55584 ACG55585 ACG55586 EAW66621 EAW66622 | ||||||||||||||||||||||||||
RNA Seq Atlas | 4772 | ||||||||||||||||||||||||||