Version 5.4
Homo sapiens Gene: SLC12A6
Summary
InnateDB Gene IDBG-5416.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC12A6
Gene Name solute carrier family 12 (potassium/chloride transporters), member 6
Synonyms ACCPN; KCC3; KCC3A; KCC3B
Species Homo sapiens
Ensembl Gene ENSG00000140199
Encoded Proteins
IDBP-5418
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-5420
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-234669
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-234671
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-364472
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-599537
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-585338
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-602617
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-591238
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-603278
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-594637
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-585040
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-594345
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-600412
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-593416
solute carrier family 12 (potassium/chloride transporters), member 6
IDBP-603816
solute carrier family 12 (potassium/chloride transporters), member 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:34229996-34338060
Strand Reverse strand
Band q14
Transcripts
ENST00000354181 ENSP00000346112
ENST00000290209 ENSP00000290209
ENST00000397707 ENSP00000380819
ENST00000397702 ENSP00000380814
ENST00000458406 ENSP00000387725
ENST00000560611 ENSP00000454168
ENST00000559523 ENSP00000452904
ENST00000559664 ENSP00000453702
ENST00000560164 ENSP00000452705
ENST00000561080 ENSP00000454069
ENST00000558667 ENSP00000453473
ENST00000558589 ENSP00000452776
ENST00000559076
ENST00000559441
ENST00000558950
ENST00000560023
ENST00000560332 ENSP00000454037
ENST00000561120 ENSP00000452771
ENST00000559236 ENSP00000452828
ENST00000559484 ENSP00000452857
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015079 potassium ion transmembrane transporter activity
GO:0015377 cation:chloride symporter activity
GO:0015379 potassium:chloride symporter activity
GO:0019901 protein kinase binding
GO:0035827 rubidium ion transmembrane transporter activity
Biological Process
GO:0001525 angiogenesis
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006821 chloride transport
GO:0010107 potassium ion import
GO:0035826 rubidium ion transport
GO:0055085 transmembrane transport
GO:0071476 cellular hypotonic response
GO:0071477 cellular hypotonic salinity response
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027130
View Gene Order
ENSBTAG00000016236
Not yet available
Pathways
NETPATH
REACTOME
REACT_19315
Cation-coupled Chloride cotransporters pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL H0YKJ2 H0YKL8
UniProt Splice Variant
Entrez Gene 9990
UniGene Hs.510939
RefSeq NM_001042494 NM_001042495 NM_001042496 NM_001042497 NM_005135 NM_133647 XM_006720793
HUGO HGNC:10914
OMIM 604878
CCDS CCDS10036 CCDS42010 CCDS42011 CCDS42012 CCDS58352
HPRD 09220
IMGT
EMBL AC021822 AC079203
GenPept
RNA Seq Atlas 9990

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca