Version 5.4
Homo sapiens Gene: SEC23A
Summary
InnateDB Gene IDBG-5190.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SEC23A
Gene Name Sec23 homolog A (S. cerevisiae)
Synonyms CLSD
Species Homo sapiens
Ensembl Gene ENSG00000100934
Encoded Proteins
IDBP-5192
Sec23 homolog A (S. cerevisiae)
IDBP-600190
Sec23 homolog A (S. cerevisiae)
IDBP-587644
Sec23 homolog A (S. cerevisiae)
IDBP-596890
Sec23 homolog A (S. cerevisiae)
IDBP-595223
Sec23 homolog A (S. cerevisiae)
IDBP-585271
Sec23 homolog A (S. cerevisiae)
IDBP-595733
Sec23 homolog A (S. cerevisiae)
IDBP-590287
Sec23 homolog A (S. cerevisiae)
IDBP-592290
Sec23 homolog A (S. cerevisiae)
IDBP-599937
Sec23 homolog A (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:39031919-39109646
Strand Reverse strand
Band q21.1
Transcripts
ENST00000307712 ENSP00000306881
ENST00000554615
ENST00000537403 ENSP00000444193
ENST00000545328 ENSP00000445393
ENST00000555363
ENST00000553925
ENST00000555682
ENST00000555017 ENSP00000450819
ENST00000556092 ENSP00000451230
ENST00000548032 ENSP00000447489
ENST00000555425 ENSP00000451999
ENST00000557280 ENSP00000452575
ENST00000553970 ENSP00000451924
ENST00000557437 ENSP00000452390
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 72 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 72 [view]
Protein-Protein 71 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
Biological Process
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0006886 intracellular protein transport
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0016192 vesicle-mediated transport
GO:0018279 protein N-linked glycosylation via asparagine
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0048208 COPII vesicle coating
GO:0061024 membrane organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0012507 ER to Golgi transport vesicle membrane
GO:0030127 COPII vesicle coat
GO:0030134 ER to Golgi transport vesicle
GO:0030868 smooth endoplasmic reticulum membrane
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020986
View Gene Order
ENSBTAG00000003708
Not yet available
Pathways
NETPATH
REACTOME
REACT_75795
Antigen Presentation: Folding, assembly and peptide loading of class I MHC pathway
REACT_121399
MHC class II antigen presentation pathway
REACT_12507
COPII (Coat Protein 2) Mediated Vesicle Transport pathway
REACT_25046
Transport to the Golgi and subsequent modification pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_11203
ER to Golgi Transport pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_111217
Metabolism pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.272927
RefSeq NM_006364
HUGO
OMIM
CCDS CCDS9668
HPRD 06714
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca