Version 5.4
Homo sapiens Gene: DNMT3L
Summary
InnateDB Gene IDBG-5125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNMT3L
Gene Name DNA (cytosine-5-)-methyltransferase 3-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000142182
Encoded Proteins
IDBP-5127
DNA (cytosine-5-)-methyltransferase 3-like
IDBP-369751
DNA (cytosine-5-)-methyltransferase 3-like
IDBP-369769
DNA (cytosine-5-)-methyltransferase 3-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a nuclear protein with similarity to DNA methyltransferases, but is not thought to function as a DNA methyltransferase as it does not contain the amino acid residues necessary for methyltransferase activity. However, it does stimulate de novo methylation by DNA cytosine methyltransferase 3 alpha and is thought to be required for the establishment of maternal genomic imprints. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:44246339-44262216
Strand Reverse strand
Band q22.3
Transcripts
ENST00000270172 ENSP00000270172
ENST00000436357 ENSP00000411608
ENST00000431166 ENSP00000400242
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 20 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008047 enzyme activator activity
GO:0019899 enzyme binding
GO:0046872 metal ion binding
Biological Process
GO:0006306 DNA methylation
GO:0006349 regulation of gene expression by genetic imprinting
GO:0007283 spermatogenesis
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000730
View Gene Order
ENSBTAG00000014882
Not yet available
Pathways
NETPATH
REACTOME
REACT_200857
Epigenetic regulation of gene expression pathway
REACT_267652
DNA methylation pathway
REACT_71
Gene Expression pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 29947
UniGene Hs.592165
RefSeq NM_013369 NM_175867 XM_006723911
HUGO HGNC:2980
OMIM 606588
CCDS CCDS13705
HPRD 09417
IMGT
EMBL
GenPept
RNA Seq Atlas 102724184 29947

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca