Version 5.4
Homo sapiens Gene: ICOSLG
Summary
InnateDB Gene IDBG-5107.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICOSLG
Gene Name inducible T-cell co-stimulator ligand
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000160223
Encoded Proteins
IDBP-5109
inducible T-cell co-stimulator ligand
IDBP-228396
inducible T-cell co-stimulator ligand
IDBP-228400
inducible T-cell co-stimulator ligand
IDBP-294472
inducible T-cell co-stimulator ligand
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 21:44222991-44240966
Strand Reverse strand
Band q22.3
Transcripts
ENST00000344330 ENSP00000339477
ENST00000400379 ENSP00000383230
ENST00000400377 ENSP00000383228
ENST00000407780 ENSP00000384432
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
Biological Process
GO:0006952 defense response
GO:0006972 hyperosmotic response
GO:0007165 signal transduction
GO:0031295 T cell costimulation
GO:0042104 positive regulation of activated T cell proliferation
GO:0042110 T cell activation
GO:0042113 B cell activation
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
NetPath_11
TCR pathway
REACTOME
REACT_19344
Costimulation by the CD28 family pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
hsa04672
Intestinal immune network for IgA production pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.14155
RefSeq NM_001283050 NM_001283051 NM_001283052 NM_015259 XM_005261098
HUGO
OMIM
CCDS CCDS42952 CCDS63377 CCDS63379
HPRD 05757
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca