Version 5.4
Homo sapiens Gene: FAN1
Summary
InnateDB Gene IDBG-4900.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FAN1
Gene Name FANCD2/FANCI-associated nuclease 1
Synonyms KIAA1018; KMIN; MTMR15
Species Homo sapiens
Ensembl Gene ENSG00000198690
Encoded Proteins
IDBP-4902
FANCD2/FANCI-associated nuclease 1
IDBP-746056
IDBP-746546
IDBP-746344
IDBP-747504
IDBP-746663
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the myotubularin-related class 1 cysteine-based protein tyrosine phosphatases. The encoded protein may be catalytically inactive. Alternatively spliced transcript variants have been described. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:30903852-30943108
Strand Forward strand
Band q13.3
Transcripts
ENST00000362065 ENSP00000354497
ENST00000561594 ENSP00000455983
ENST00000561607 ENSP00000454223
ENST00000562881
ENST00000565280 ENSP00000455573
ENST00000565466 ENSP00000454544
ENST00000562892 ENSP00000457680
ENST00000568145
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003677 DNA binding
GO:0004528 phosphodiesterase I activity
GO:0005515 protein binding
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0043130 ubiquitin binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0033683 nucleotide-excision repair, DNA incision
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000033458
View Gene Order
ENSBTAG00000009855
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.584863 Hs.627114
RefSeq NM_001146094 NM_001146095 NM_001146096 NM_014967 XM_005254232 XM_005254233 XM_005254234 XM_005254235 XM_006725537 XM_006725538 XM_006725539 XM_006725540
HUGO
OMIM
CCDS CCDS32186 CCDS58344
HPRD 17205
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca