Version 5.4
Homo sapiens Gene: PSMA6
Summary
InnateDB Gene IDBG-4735.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PSMA6
Gene Name proteasome (prosome, macropain) subunit, alpha type, 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000100902
Encoded Proteins
IDBP-4737
proteasome (prosome, macropain) subunit, alpha type, 6
IDBP-597938
proteasome (prosome, macropain) subunit, alpha type, 6
IDBP-603502
proteasome (prosome, macropain) subunit, alpha type, 6
IDBP-602761
proteasome (prosome, macropain) subunit, alpha type, 6
IDBP-599228
proteasome (prosome, macropain) subunit, alpha type, 6
IDBP-599713
proteasome (prosome, macropain) subunit, alpha type, 6
IDBP-597773
proteasome (prosome, macropain) subunit, alpha type, 6
IDBP-602747
proteasome (prosome, macropain) subunit, alpha type, 6
IDBP-595138
proteasome (prosome, macropain) subunit, alpha type, 6
IDBP-589987
proteasome (prosome, macropain) subunit, alpha type, 6
IDBP-808650
proteasome (prosome, macropain) subunit, alpha type, 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. A pseudogene has been identified on the Y chromosome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:35278633-35317493
Strand Forward strand
Band q13.2
Transcripts
ENST00000261479 ENSP00000261479
ENST00000540871 ENSP00000444844
ENST00000554541 ENSP00000451958
ENST00000554843
ENST00000554620 ENSP00000451432
ENST00000554961 ENSP00000451254
ENST00000556167
ENST00000553809 ENSP00000452603
ENST00000553688 ENSP00000450844
ENST00000555764 ENSP00000452566
ENST00000556506 ENSP00000450528
ENST00000555050
ENST00000556221 ENSP00000451171
ENST00000554457
ENST00000622405 ENSP00000479620
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 137 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 137 [view]
Protein-Protein 137 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity
GO:0005515 protein binding
GO:0035639 purine ribonucleoside triphosphate binding
GO:0051059 NF-kappaB binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0000278 mitotic cell cycle
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0006521 regulation of cellular amino acid metabolic process
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0044281 small molecule metabolic process
GO:0050727 regulation of inflammatory response
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051603 proteolysis involved in cellular protein catabolic process
Cellular Component
GO:0000932 cytoplasmic mRNA processing body
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005839 proteasome core complex
GO:0005844 polysome
GO:0016363 nuclear matrix
GO:0019773 proteasome core complex, alpha-subunit complex
GO:0030016 myofibril
GO:0030017 sarcomere
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021024
View Gene Order
ENSBTAG00000009683
Not yet available
Pathways
NETPATH
REACTOME
REACT_20549
Autodegradation of the E3 ubiquitin ligase COP1 pathway
REACT_309
Stabilization of p53 pathway
REACT_1625
p53-Dependent G1 DNA Damage Response pathway
REACT_1614
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
REACT_2160
p53-Independent DNA Damage Response pathway
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_6871
APC/C:Cdc20 mediated degradation of Securin pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6785
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_6821
SCF-beta-TrCP mediated degradation of Emi1 pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_1221
CDK-mediated phosphorylation and removal of Cdc6 pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_4
Ubiquitin-dependent degradation of Cyclin D1 pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_9003
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1949
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_111178
ER-Phagosome pathway pathway
REACT_111056
Cross-presentation of soluble exogenous antigens (endosomes) pathway
REACT_118656
Activation of NF-kappaB in B cells pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_25325
AUF1 (hnRNP D0) destabilizes mRNA pathway
REACT_13464
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
REACT_13565
Regulation of ornithine decarboxylase (ODC) pathway
REACT_9453
Vif-mediated degradation of APOBEC3G pathway
REACT_9031
Vpu mediated degradation of CD4 pathway
REACT_383
DNA Replication pathway
REACT_172581
PCP/CE pathway pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_85
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_1208
p53-Independent G1/S DNA damage checkpoint pathway
REACT_228190
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_2014
Synthesis of DNA pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_11045
Signaling by Wnt pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_899
S Phase pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_206597
Degradation of GLI2 by the proteasome pathway
REACT_200841
degradation of DVL pathway
REACT_231645
GLI3 is processed to GLI3R by the proteasome pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_267605
Degradation of GLI1 by the proteasome pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_1783
G1/S Transition pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228209
Hh ligand biogenesis disease pathway
REACT_938
Ubiquitin-dependent degradation of Cyclin D pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_115566
Cell Cycle pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_6900
Immune System pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_910
M Phase pathway
REACT_228111
Hedgehog ligand biogenesis pathway
REACT_1275
Mitotic Anaphase pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
REACT_1725
M/G1 Transition pathway
REACT_200766
degradation of AXIN pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_6185
HIV Infection pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_2254
G1/S DNA Damage Checkpoints pathway
REACT_111217
Metabolism pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_829
Regulation of DNA replication pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_13648
Regulation of Apoptosis pathway
REACT_71
Gene Expression pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa03050
Proteasome pathway
INOH
INOH website
TGF-beta signaling pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.446260 Hs.602113 Hs.667699 Hs.708997
RefSeq NM_001282232 NM_001282233 NM_001282234 NM_002791
HUGO
OMIM
CCDS CCDS61437 CCDS61438 CCDS9655
HPRD 04171
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca