Version 5.4
Homo sapiens Gene: SIK1
Summary
InnateDB Gene IDBG-4715.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIK1
Gene Name salt-inducible kinase 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000142178
Encoded Proteins
IDBP-4717
salt-inducible kinase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 21:43414515-43427128
Strand Reverse strand
Band q22.3
Transcripts
ENST00000270162 ENSP00000270162
ENST00000478426
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008140 cAMP response element binding protein binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0019901 protein kinase binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0002028 regulation of sodium ion transport
GO:0006468 protein phosphorylation
GO:0007049 cell cycle
GO:0007346 regulation of mitotic cell cycle
GO:0010830 regulation of myotube differentiation
GO:0010868 negative regulation of triglyceride biosynthetic process
GO:0032792 negative regulation of CREB transcription factor activity
GO:0035556 intracellular signal transduction
GO:0045595 regulation of cell differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0046777 protein autophosphorylation
GO:0055007 cardiac muscle cell differentiation
GO:2000210 positive regulation of anoikis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024042
View Gene Order
ENSBTAG00000011437
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
KEGG
INOH
PID NCI
lkb1_pathway
LKB1 signaling events
Cross-References
SwissProt P57059
TrEMBL
UniProt Splice Variant
Entrez Gene 150094
UniGene Hs.282113 Hs.700423
RefSeq NM_173354
HUGO HGNC:11142
OMIM 605705
CCDS CCDS33575
HPRD
IMGT
EMBL AB047786 AK131076 AP001751 BC038504
GenPept AAH38504 BAA95536 BAC85126 BAD74070
RNA Seq Atlas 150094

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca