Version 5.4
Homo sapiens Gene: EIF4ENIF1
Summary
InnateDB Gene IDBG-4689.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF4ENIF1
Gene Name eukaryotic translation initiation factor 4E nuclear import factor 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000184708
Encoded Proteins
IDBP-4691
eukaryotic translation initiation factor 4E nuclear import factor 1
IDBP-4695
eukaryotic translation initiation factor 4E nuclear import factor 1
IDBP-235154
eukaryotic translation initiation factor 4E nuclear import factor 1
IDBP-235156
eukaryotic translation initiation factor 4E nuclear import factor 1
IDBP-235158
eukaryotic translation initiation factor 4E nuclear import factor 1
IDBP-235160
eukaryotic translation initiation factor 4E nuclear import factor 1
IDBP-372905
eukaryotic translation initiation factor 4E nuclear import factor 1
IDBP-372907
eukaryotic translation initiation factor 4E nuclear import factor 1
IDBP-372916
eukaryotic translation initiation factor 4E nuclear import factor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a nucleocytoplasmic shuttle protein for the translation initiation factor eIF4E. This shuttle protein interacts with the importin alpha-beta complex to mediate nuclear import of eIF4E. It is predominantly cytoplasmic; its own nuclear import is regulated by a nuclear localization signal and nuclear export signals. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:31436977-31496108
Strand Reverse strand
Band q12.2
Transcripts
ENST00000330125 ENSP00000328103
ENST00000344710 ENSP00000342927
ENST00000397525 ENSP00000380659
ENST00000397523 ENSP00000380657
ENST00000397520 ENSP00000380654
ENST00000397518 ENSP00000380652
ENST00000445424 ENSP00000395293
ENST00000418321 ENSP00000413690
ENST00000423097 ENSP00000405086
ENST00000495101
ENST00000475437
ENST00000487671
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 24 [view]
Protein-Protein 21 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006413 translational initiation
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0016605 PML body
GO:0016607 nuclear speck
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020454
View Gene Order
ENSBTAG00000008991
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.517559
RefSeq NM_001164501 NM_001164502 NM_019843 XM_005261686 XM_005261687 XM_005261688 XM_006724281 XM_006724282 XM_006724283 XM_006724284
HUGO
OMIM
CCDS CCDS13898 CCDS54520
HPRD 10456
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca