InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PRKD1

Summary

InnateDB Gene

IDBG-4215.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKD1

Gene Name

protein kinase D1

Synonyms

PKC-MU; PKCM; PKD; PRKCM

Species

Homo sapiens

Ensembl Gene

ENSG00000184304

Encoded Proteins

IDBP-4217

protein kinase D1

IDBP-364837

protein kinase D1

IDBP-589107

protein kinase D1

IDBP-592625

protein kinase D1

IDBP-589491

protein kinase D1

IDBP-811816

protein kinase D1

IDBP-811818

protein kinase D1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

PRKD1 is a serine/threonine kinase that regulates a variety of cellular functions, including membrane receptor signaling, transport at the Golgi, protection from oxidative stress at the mitochondria, gene transcription, and regulation of cell shape, motility, and adhesion (summary by Eiseler et al., 2009 [PubMed 19329994]).[supplied by OMIM, Nov 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:29576479-30191898

Strand

Reverse strand

Band

q12

Transcripts

ENST00000331968	ENSP00000333568
ENST00000415220	ENSP00000390535
ENST00000490795	ENSP00000447723
ENST00000468370
ENST00000546371	ENSP00000447333
ENST00000551644
ENST00000547441
ENST00000549503	ENSP00000446866
ENST00000616995	ENSP00000482645
ENST00000621126	ENSP00000483466

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 48 experimentally validated interaction(s) in this database.

Experimentally validated
Total	48 [view]
Protein-Protein	48 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004697	protein kinase C activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0042802	identical protein binding
GO:0046872	metal ion binding

Biological Process

GO:0001525	angiogenesis
GO:0001938	positive regulation of endothelial cell proliferation
GO:0006468	protein phosphorylation
GO:0006665	sphingolipid metabolic process
GO:0006915	apoptotic process
GO:0006954	inflammatory response
GO:0007030	Golgi organization
GO:0007165	signal transduction
GO:0007229	integrin-mediated signaling pathway
GO:0008283	cell proliferation
GO:0010595	positive regulation of endothelial cell migration
GO:0010837	regulation of keratinocyte proliferation
GO:0010976	positive regulation of neuron projection development
GO:0018105	peptidyl-serine phosphorylation
GO:0030148	sphingolipid biosynthetic process
GO:0032793	positive regulation of CREB transcription factor activity
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0034599	cellular response to oxidative stress
GO:0035556	intracellular signal transduction
GO:0035924	cellular response to vascular endothelial growth factor stimulus
GO:0038033	positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043536	positive regulation of blood vessel endothelial cell migration
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response
GO:0045669	positive regulation of osteoblast differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045806	negative regulation of endocytosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046777	protein autophosphorylation
GO:0048010	vascular endothelial growth factor receptor signaling pathway
GO:0048193	Golgi vesicle transport
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0060548	negative regulation of cell death
GO:1901727	positive regulation of histone deacetylase activity
GO:2001028	positive regulation of endothelial cell chemotaxis
GO:2001044	regulation of integrin-mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005802	trans-Golgi network
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0005938	cell cortex