InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SF3A1

Summary

InnateDB Gene

IDBG-4041.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SF3A1

Gene Name

splicing factor 3a, subunit 1, 120kDa

Synonyms

PRP21; PRPF21; SAP114; SF3A120

Species

Homo sapiens

Ensembl Gene

ENSG00000099995

Encoded Proteins

IDBP-4043

splicing factor 3a, subunit 1, 120kDa

IDBP-371692

splicing factor 3a, subunit 1, 120kDa

IDBP-371695

splicing factor 3a, subunit 1, 120kDa

IDBP-371699

splicing factor 3a, subunit 1, 120kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25658809

[Mus musculus] Sf3a1 affects the mRNA splicing of genes in the TLR signalling pathway to modulate the innate immune response in macrophages.

Entrez Gene

Summary

This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
This gene encodes a subunit of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer is a component of the mature U2 small nuclear ribonucleoprotein particle (snRNP). U2 small nuclear ribonucleoproteins play a critical role in spliceosome assembly and pre-mRNA splicing. [provided by RefSeq, Aug 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:30331988-30356947

Strand

Reverse strand

Band

q12.2

Transcripts

ENST00000215793	ENSP00000215793
ENST00000411423	ENSP00000412715
ENST00000444440	ENSP00000400862
ENST00000447376	ENSP00000397267
ENST00000485618
ENST00000498259
ENST00000471037
ENST00000471342
ENST00000463818
ENST00000496189

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 149 experimentally validated interaction(s) in this database.

Experimentally validated
Total	149 [view]
Protein-Protein	144 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000389	mRNA 3'-splice site recognition
GO:0000398	mRNA splicing, via spliceosome
GO:0006396	RNA processing
GO:0006397	mRNA processing
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005684	U2-type spliceosomal complex
GO:0071013	catalytic step 2 spliceosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000002129

View Gene Order

ENSBTAG00000003390

Not yet available

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.406277 Hs.626979

RefSeq

NM_001005409 NM_005877

HUGO

OMIM

CCDS

CCDS13875

HPRD

06903

IMGT

EMBL

GenPept

RNA Seq Atlas