InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: OSM

Summary

InnateDB Gene

IDBG-4002.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OSM

Gene Name

oncostatin M

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000099985

Encoded Proteins

IDBP-4004

oncostatin M

IDBP-294596

oncostatin M

IDBP-294595

oncostatin M

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25692402

[Mus musculus] Stat3 is required for maximal Osm-induced lung Cxcl5 expression and subsequent neutrophil recruitment during bacterial pneumonia.

Entrez Gene

Summary

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 22:30262829-30266840

Strand

Reverse strand

Band

q12.2

Transcripts

ENST00000215781	ENSP00000215781
ENST00000403389	ENSP00000383893
ENST00000403463	ENSP00000384543

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005147	oncostatin-M receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0002675	positive regulation of acute inflammatory response
GO:0006955	immune response
GO:0007275	multicellular organismal development
GO:0007422	peripheral nervous system development
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0009408	response to heat
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0040008	regulation of growth
GO:0042503	tyrosine phosphorylation of Stat3 protein
GO:0042506	tyrosine phosphorylation of Stat5 protein
GO:0042508	tyrosine phosphorylation of Stat1 protein
GO:0043410	positive regulation of MAPK cascade
GO:0045835	negative regulation of meiosis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0046888	negative regulation of hormone secretion
GO:0048266	behavioral response to pain
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0051781	positive regulation of cell division
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005900	oncostatin-M receptor complex

Orthologs

Species

Mus musculus

Gene ID

Gene Order

ENSMUSG00000058755

View Gene Order

Pathways

NETPATH

NetPath_114

Oncostatin_M pathway

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

hsa04630

Jak-STAT signaling pathway pathway

INOH

PID NCI

il3_pathway

IL3-mediated signaling events

gmcsf_pathway

GMCSF-mediated signaling events

Cross-References

SwissProt

TrEMBL

B5BUQ7 B5MCX1

UniProt Splice Variant

Entrez Gene

5008

UniGene

Hs.248156

RefSeq

NM_020530 XM_005261623

HUGO

HGNC:8506

OMIM

165095

CCDS

CCDS13873

HPRD

01300

IMGT

EMBL

AB451493 AC004264

GenPept

BAG70307

RNA Seq Atlas

5008